Investigating the Effect of 4-week Omega-3 Polyunsaturated Fatty Acid Supplementation on Inflammation (STC)

Bethan Hussey

Status

Unknown

Conditions

Healthy

Treatments

Dietary Supplement: Omega-3 Polyunsaturated Fatty Acids Supplementation

Study type

Interventional

Funder types

Other

Identifiers

NCT03210805

R16-P138

Details and patient eligibility

About

Investigate the in vivo effects of n-3 PUFA supplementation on inflammation, gene expression and epigenetic signatures.

Ex vivo stimulation of peripheral blood mononuclear cells (PBMCs) collected pre and post n-3 supplementation and measurement of it's effect on inflammation, gene expression and epigenetic signatures.

Enrollment

17 patients

Sex

Male

Ages

18 to 30 years old

Volunteers

Accepts Healthy Volunteers

Inclusion criteria

Healthy males
Aged between 18 and 30 years

Exclusion criteria

Females (Due to differences in cell membrane incorporation of n-3 PUFAs between the sexes and the testing schedule being unable to fit in with menstrual cycle, therefore altering the blood markers that are being measured).
Aged below 18 or above 30.
Body mass index (BMI; in kg/ m2), below 18 or above 30.
Use of vitamin or fish oil supplements in the last 6 months.
High habitual oily fish consumption (<4 servings per month).
Smoking.
Changes in weight in the past 6 months (Dieting) or planning on changing dietary habits.
Habitual use of anti-inflammatory drugs.
Self-reported history of diabetes.
History of heart disease, coagulation/bleeding disorders, metabolic disease or Serious allergy.
Known to have blood-borne virus.
Receipt of inoculations within 2 months of starting the study or the intention to receive such during the study.
Donation of or intention to donate blood within 8 weeks of the first sample or at any point during the intervention.