Investigating the Effect of Obesity on Eosinophil Recruitment in Human Adipose Tissue

Mayo Clinic

Status: Completed

Conditions: Healthy; Obese

Treatments: Procedure: Fat Tissue Biopsy

Study type: Interventional

Funder types: Other

Identifiers

NCT04234295

19-003803

Details and patient eligibility

About

Researchers are trying to better understand the relationship between inflammation in adipose tissue (AT) and insulin resistance.

Enrollment: 24 patients

Sex: All

Ages: 30 to 50 years old

Volunteers: Accepts Healthy Volunteers

Inclusion criteria

• Adults ages 30-50 years
• Non-smokers
• Lean subjects with a BMI of 25 or less, gender specific normal body fat,
• Obese, non-diabetic subjects with a BMI between 30 and 50 and taking no medications affecting glucose metabolism or lipid metabolism
• subjects scheduled for an elective laparoscopic or laparotomy abdominal surgery

Exclusion criteria

• Receiving corticosteroid therapy or have a history of asthma, COPD or atopic syndrome
• taking any biologic treatment for any autoimmune disorder
• Taking any leukotriene receptor antagonist acting medications (ex. Montelukast)
• smoking

Trial design

Primary purpose: Basic Science

Allocation: Non-Randomized

Interventional model: Parallel Assignment

Masking: None (Open label)

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24 participants in 2 patient groups

Lean, Healthy Controls

Active Comparator group

Description:

Subjects with a body mass index (BMI) of 25 or less will have a fat tissue biopsy collected

Treatment:

Procedure: Fat Tissue Biopsy

Obese, Non-Diabetic

Experimental group

Description:

Subject with a BMI between 30 and 50 kg/m2 will have fat tissue biopsy collected

Treatment:

Procedure: Fat Tissue Biopsy