Investigating the Effect of Whole-fruit Coffee Extract on Exercise Performance (PACE)

University of Exeter

Status

Completed

Conditions

Caffine and Endurance Performance

Treatments

Dietary Supplement: Placebo

Dietary Supplement: CoffeeBerry Supplement

Study type

Interventional

Funder types

Other

Industry

Identifiers

NCT05404841

2021-10-20-B-05

Details and patient eligibility

About

Caffeine is a widely used efficacious supplement by both the general public, and athletes, with the goal of improving performance. The effects of caffeine alone are well known, but it is not clear whether a multi-ingredient supplement (containing both caffeine and polyphenols) can affect exercise performance.

This study aims to determine if a low dose of caffeine, in the form of a whole-fruit coffee extract also containing polyphenols, can improve exercise performance compared to a placebo condition, with a secondary objective of identifying if this supplement can improve post exercise refuelling (glycogen resynthesis).

Participants will consume either the supplement or a placebo before engaging in an exercise protocol. Muscle biopsies will then be obtained so as to measure subsequent glycogen resynthesis, with multiple blood samples being taken through the day. The following morning another biopsy will be taken before the exercise protocol will be repeated.

This research will inform us of the efficacy of caffeine and polyphenols on improving exercise performance.

Enrollment

14 patients

Sex

All

Ages

18 to 40 years old

Volunteers

Accepts Healthy Volunteers

Inclusion and exclusion criteria

Exclusion criteria:

Allergy to Lidocaine
Exclusion critera
Any diagnosed metabolic health condition
Pregnant
Non-habitual caffeine intake
Smoker
No endurance training
Diagnosed Cardiovascular disease
Beta-Blockers
Recent history of musculoskeletal injury

Inclusion criteria:

Age 18-40
Heathy
Highly trained endurance athletes (V̇O2max: males >55 and females >50 mL⋅kg bm-1⋅min-1)
Both males and females are allowed to participate. If females are on the oral contraceptive pill they are to be tested on consecutive weeks. If they are not on the oral contraceptive pill, then female subjects are to be tested every 4 weeks, at the same point of their menstrual cycle.