Investigating the Physiology of Targeted Theta-burst Neuromodulation

Institute of Mental Health Nottingham

Status: Completed

Conditions: Healthy Volunteers

Treatments: Device: sham theta-burst TMS; Device: theta-burst TMS

Study type: Interventional

Funder types: Other

Identifiers

NCT02616835

L14082014 SoM PAPsych

Details and patient eligibility

About

This research seeks to study the physiological effects of theta-burst transcranial magnetic stimulation (TMS) in the brains of healthy controls using functional MRI and spectroscopy.

Enrollment: 28 patients

Sex: All

Ages: 18 to 65 years old

Volunteers: Accepts Healthy Volunteers

Inclusion criteria

• No personal history of neurological or psychiatric disorders

Exclusion criteria

• Have had a brain injury or neurological disorder
• Have ever suffered an epileptic fit
• Have any non-removable metal implants
• Drink more than 20 units of alcohol per week on a regular basis
• Currently take any illicit drugs on regular basis
• Likely to be pregnant
• Ever suffered from a serious mental illness such as schizophrenia, severe depression or bipolar disorder
• Currently take any psychotropic medication

Trial design

Primary purpose: Basic Science

Allocation: Randomized

Interventional model: Crossover Assignment

Masking: Single Blind

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28 participants in 2 patient groups

theta-burst TMS

Experimental group

Description:

Theta-Burst protocol for transcranial magnetic stimulation on dorsolateral prefrontal cortex (exact location to be determined using neuronavigation guided by Magnetic Resonance Imaging)

Treatment:

Device: theta-burst TMS

sham theta-burst TMS

Sham Comparator group

Description:

Sham protocol for theta-burst transcranial magnetic stimulation on dorsolateral prefrontal cortex (exact location to be determined using neuronavigation guided by Magnetic Resonance Imaging)

Treatment:

Device: sham theta-burst TMS