Investigating the Role of Brain-derived Neurotrophic Factor (BDNF) Between Pain and Other Neuronal Disease

National Cheng-Kung University

Status: Completed

Conditions: Pain

Treatments: Behavioral: pain evaluation

Study type: Observational

Funder types: Other

Identifiers

NCT03606915

B-ER-104-070

Details and patient eligibility

About

Measure the cytokines, transforming or neurotrophic factors in CSF and plasma as the pain markers and as a new therapeutic target for pain control.

Full description

The research protocol was approved by the Institutional Review Board (IRB) for the Protection of Human Subjects at National Cheng Kung University Hospital (NCKUH/B-ER-104-070). The study procedures were performed according to the rules of IRB and fully explained to the participants. Blood and CSF samples were collected and compared the difference in no pain group, acute pain group, and chronic pain group.

Enrollment: 131 patients

Sex: All

Ages: 20 to 90 years old

Volunteers: No Healthy Volunteers

Inclusion criteria

• . Patients undergo spinal anesthesia

• . Over 20 years of age

  • Patients who are competent to understand the study and provide written informed consent.

Exclusion criteria

• Patients have the contraindication for spinal anesthesia (refuse spinal anesthesia, coagulopathy, severe aortic stenosis)
• Refuse participated in this study or pre-existent neurological disease.
• Patients with advanced tumor staging (stage 3 or 4).

Trial design

131 participants in 3 patient groups

no pain

Description:

pain evaluation for patients performed surgery without painful condition (bleeding or others)

Treatment:

Behavioral: pain evaluation

acute pain

Description:

pain evaluation for patients performed surgery with painful condition within several days

Treatment:

Behavioral: pain evaluation

chronic pain

Description:

pain evaluation for patients performed surgery with the painful condition for over months

Treatment:

Behavioral: pain evaluation