Status and phase
Conditions
Treatments
Study type
Funder types
Identifiers
About
The purpose of this study is to investigate what side effects the new compound LEO 158968 might cause and how well it is tolerated when it is used by healthy participants. It will also investigate how quickly and to what extent LEO 158968 is distributed and eliminated from the body and if LEO 158968 causes the body to make antibodies.
In the single ascending dose (SAD) cohorts, participants will receive escalating doses of LEO 158968 if the safety and tolerability results of the initial participants up to 48 hours (or 4 days for SC dosing) following dosing are acceptable to the Investigator.
In the multiple ascending dose (MAD) cohorts, the dose of LEO 158968 will be determined based on results derived from the earlier SAD cohorts and additional preclinical data from a 5-week good laboratory practice (GLP) cynomolgus monkey toxicology study.
Enrollment
Sex
Ages
Volunteers
Inclusion criteria
Exclusion criteria
A participant who meets any of the following exclusion criteria will not be eligible for inclusion in the study:
Primary purpose
Allocation
Interventional model
Masking
120 participants in 2 patient groups
Loading...
Central trial contact
Clinical Disclosure
Data sourced from clinicaltrials.gov
Clinical trials
Research sites
Resources
Legal