Investigating the SMA's Role in Speech and Reading Fluency in PWS with RTMS

Medipol University

Status: Invitation-only

Conditions: Stuttering, Adult

Treatments: Other: Brain stimulation

Study type: Interventional

Funder types: Other

Identifiers

NCT06809387

E-10840098-202.3.02-645

Details and patient eligibility

About

The goal of this clinical trial is to study how a part of the brain called the supplementary motor area (SMA) is connected to speech and reading fluency in adults who stutter. Researchers will use a method called repetitive transcranial magnetic stimulation (rTMS) to learn more about this relationship. The main question it aims to answer is:

-Will participants' speech and reading fluency improve when we stimulate the SMA with rTMS?

Participants will take part in both placebo rTMS and real rTMS sessions.

Participants will:

• Come to the research center for 2 days, with at least a one-week break between visits
• Read 4 passages and speak on 4 topics
• Be video recorded while doing these tasks

Enrollment: 15 estimated patients

Sex: Male

Ages: 18+ years old

Volunteers: Accepts Healthy Volunteers

Inclusion criteria

• To be over 18 years of age
• Presence of developmental stuttering
• Being right hand dominant

Exclusion criteria

• Being under 18 years of age
• The presence of a diagnosed brain lesion
• Presence of intracranial metal implantation
• Presence of a speech and language problem other than stuttering
• The presence of a diagnosed neurological disorder
• The presence of a diagnosed psychiatric disorder
• Use of drugs and substances that may affect the central nervous system
• History of epilepsy

Trial design

Primary purpose: Other

Allocation: Non-Randomized

Interventional model: Crossover Assignment

Masking: Single Blind

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15 participants in 2 patient groups, including a placebo group

Real rTMS

Experimental group

Description:

Participants will be included in the real rTMS. Participants will perform speech and reading tasks before and after stimulation.

Treatment:

Other: Brain stimulation

Sham rTMS

Placebo Comparator group

Description:

Participants will be included in the sham rTMS. Participants will perform speech and reading tasks before and after stimulation.

Treatment:

Other: Brain stimulation