Investigating the Specificity of Neural Correlates for Emotion Processing Deficits in Conduct Disorder and Autism Spectrum Disorders
Status
Unknown
Conditions
Autism-Spectrum Disorder
Conduct Disorder
Treatments
Other: Interpersonal Reactivity Index (IRI) (for children)
Other: Reactive Proactive Questionnaire (RPQ) (for children)
Other: Alabama Parenting Questionnaire (APQ) (for parents)
Other: Basic Empathy Scale (BES) (for children)
Other: Social Responsiveness Scale (SRS) (for parents)
Other: Pubertal Development Scale (PDS) (for children)
Other: Massachusetts Youth Screening Instrument (MAYSI-2) (for children)
Other: Youth Psychopathic Traits Inventory (YPI) (for children)
Other: Social and Health Assessment (SAHA) questionnaire (for children)
Other: Emotion Regulation Questionnaire (for children)
Other: Child Behavior Checklist (CBCL) (for parents)
Other: neuroimaging session (with simultaneously acquired eye-tracking)
Other: Questionnaire (for children) assessing traumatic experiences (Childhood trauma questionnaire (CTQ))
Other: Inventory of Callous Unemotional Traits (ICU) (for parents)
Other: Griffith Empathy Measure (GEM) (for parents)
Details and patient eligibility
About
This study is
- to investigate the differential and shared neural underpinnings of facial emotion processing within Conduct disorder (CD) and Autism-Spectrum disorder (ASD) and
- to investigate the interaction between deficits in emotion processing and dysfunctional cognitive control processes.
Differences in emotion processing and the underlying neural underpinnings of such differences will be assessed by means of functional magnetic resonance imaging (fMRI) without any contrast agent, combined with adapted emotion processing paradigms and eye tracking techniques.
Enrollment
120 estimated patients
Sex
All
Ages
10 to 18 years old
Volunteers
Accepts Healthy Volunteers
Inclusion criteria
- For all participants: age between 10 and 18 years and an intelligence quotient score of 70 or higher.
- For patient groups: confirmed clinical diagnoses according to Diagnostic and Statistical Manual (DSM)-5 of CD or ASD (depending on the group), without comorbid depression or anxiety psychological disorders.
Exclusion criteria
- For all participants: low intelligence (IQ<70, as they might otherwise not fully understand what they are expected to do inside the scanner), insufficient German language skills or any contraindications for MRI (e.g. pregnancy, any non-removable metal within the subjects' body, claustrophobia).
- For patient groups: severe developmental disorders, comorbid depressive and/or anxiety disorders will also be excluded from the study since it was shown that these patients might have problems in attention allocation under emotional stimulation.
- For typically developing participants: suspicion of an undiagnosed clinical disorder
Trial design
120 participants in 3 patient groups
Conduct disorder
Description:
children and adolescents with CD
Treatment:
Other: Reactive Proactive Questionnaire (RPQ) (for children)
Other: neuroimaging session (with simultaneously acquired eye-tracking)
Other: Pubertal Development Scale (PDS) (for children)
Other: Alabama Parenting Questionnaire (APQ) (for parents)
Other: Inventory of Callous Unemotional Traits (ICU) (for parents)
Other: Social and Health Assessment (SAHA) questionnaire (for children)
Other: Griffith Empathy Measure (GEM) (for parents)
Other: Emotion Regulation Questionnaire (for children)
Other: Basic Empathy Scale (BES) (for children)
Other: Interpersonal Reactivity Index (IRI) (for children)
Other: Questionnaire (for children) assessing traumatic experiences (Childhood trauma questionnaire (CTQ))
Other: Social Responsiveness Scale (SRS) (for parents)
Other: Child Behavior Checklist (CBCL) (for parents)
Other: Youth Psychopathic Traits Inventory (YPI) (for children)
Other: Massachusetts Youth Screening Instrument (MAYSI-2) (for children)
Autism-Spectrum disorder
Description:
children and adolescents with ASD
Treatment:
Other: Reactive Proactive Questionnaire (RPQ) (for children)
Other: neuroimaging session (with simultaneously acquired eye-tracking)
Other: Pubertal Development Scale (PDS) (for children)
Other: Alabama Parenting Questionnaire (APQ) (for parents)
Other: Inventory of Callous Unemotional Traits (ICU) (for parents)
Other: Social and Health Assessment (SAHA) questionnaire (for children)
Other: Griffith Empathy Measure (GEM) (for parents)
Other: Emotion Regulation Questionnaire (for children)
Other: Basic Empathy Scale (BES) (for children)
Other: Interpersonal Reactivity Index (IRI) (for children)
Other: Questionnaire (for children) assessing traumatic experiences (Childhood trauma questionnaire (CTQ))
Other: Social Responsiveness Scale (SRS) (for parents)
Other: Child Behavior Checklist (CBCL) (for parents)
Other: Youth Psychopathic Traits Inventory (YPI) (for children)
Other: Massachusetts Youth Screening Instrument (MAYSI-2) (for children)
typically developing adolescents
Description:
typically developing adolescents
Treatment:
Other: Reactive Proactive Questionnaire (RPQ) (for children)
Other: neuroimaging session (with simultaneously acquired eye-tracking)
Other: Pubertal Development Scale (PDS) (for children)
Other: Alabama Parenting Questionnaire (APQ) (for parents)
Other: Inventory of Callous Unemotional Traits (ICU) (for parents)
Other: Social and Health Assessment (SAHA) questionnaire (for children)
Other: Griffith Empathy Measure (GEM) (for parents)
Other: Emotion Regulation Questionnaire (for children)
Other: Basic Empathy Scale (BES) (for children)
Other: Interpersonal Reactivity Index (IRI) (for children)
Other: Questionnaire (for children) assessing traumatic experiences (Childhood trauma questionnaire (CTQ))
Other: Social Responsiveness Scale (SRS) (for parents)
Other: Child Behavior Checklist (CBCL) (for parents)
Other: Youth Psychopathic Traits Inventory (YPI) (for children)
Other: Massachusetts Youth Screening Instrument (MAYSI-2) (for children)
Trial contacts and locations
1
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Central trial contact
Christina Stadler, Prof. Dr. med
Data sourced from clinicaltrials.gov
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