Investigation of a New Human Model for Itch

Aalborg University

Status

Completed

Conditions

Itch

Treatments

Other: Cowhage

Other: Histamine

Other: Papain

Other: L-menthol

Study type

Interventional

Funder types

Other

Identifiers

NCT04711044

N-20200005 (third sub-project)

Details and patient eligibility

About

This third sub-project aims to evaluate the interaction between the TRPM8 receptor and pruritus by studying the anti-pruritic effect of TPRM8-agonist L-menthol on histaminergic and non-histaminergic itch induced using three different pruritogens: histamine, cowhage and papain.

Enrollment

20 patients

Sex

All

Ages

18 to 60 years old

Volunteers

Accepts Healthy Volunteers

Inclusion criteria

Healthy men and women
18-60 years
Speak and understand English

Exclusion criteria

Pregnancy or lactation
Drug addiction defined as any use of cannabis, opioids or other addictive drugs
Previous or current history of neurological, dermatological, immunological musculoskeletal, cardiac disorder or mental illnesses that may affect the results (e.g. neuropathy, muscular pain in the upper extremities, etc.).
Lack of ability to cooperate
Current use of medications that may affect the trial such as antihistamines, antipsychotics and pain killers, as well as systemic or topical steroids.
Skin diseases
Moles, scars or tattoos in the area to be treated or tested.
Hypersensitivity to papaya and mango fruit, cashew nuts, rubber latex
Consumption of alcohol or painkillers 24 hours before the study days and between these
Acute or chronic pain
Participation in other trials within 1 week of study entry (4 weeks in the case of pharmaceutical trials)