Investigation of Analgesic and Anti-hyperalgesic Effect of Opioids in Experimental Pain

University of Aarhus

Status and phase: Completed; Phase 3

Conditions: Pain

Treatments: Drug: Fentanyl; Drug: Placebo; Drug: Buprenorphine

Study type: Interventional

Funder types: Other

Identifiers

NCT00647127

2007-004524-21

Details and patient eligibility

About

To compare the analgesic and anti-hyperalgesic effect of Buprenorphine and Fentanyl against experimental pain in skin, muscle and bone. The study will be performed with healthy volunteers.

Enrollment: 22 patients

Sex: Male

Ages: 18 to 65 years old

Volunteers: No Healthy Volunteers

Inclusion criteria

• written informed consent
• men > 18 years

Exclusion criteria

• women
• known allergy against the investigated drugs
• ongoing participation in other experiments or participation in other experiments 14 days before screening
• previously pain or psychiatric conditions
• simultaneously use of pain killers
• alcohol
• previously drug-addict or member of family with drug-addicts
• chronic constipation
• ileus
• inflammatory bowel syndrome
• abdominal surgery within the last three months

Trial design

22 participants in 3 patient groups, including a placebo group

Buprenorphine

Active Comparator group

Treatment:

Drug: Buprenorphine

Fentanyl

Active Comparator group

Treatment:

Drug: Fentanyl

Placebo

Placebo Comparator group

Treatment:

Drug: Placebo