Investigation of Brain Oxygenation and Blood Flow in Smokers (OEF)

Central Institute of Mental Health, Mannheim

Status

Completed

Conditions

Cerebral Oxygenation and Blood Flow in Tobacco Use Disorder

Treatments

Other: no intervention

Study type

Observational

Funder types

Other

Identifiers

NCT03571243

Details and patient eligibility

About

Cerebral oxygenation and blood flow in tobacco use disorder and their relation to smoking abstinence will be measured with MRI" ändern in "Cerebral oxygenation and blood flow in tobacco use disorder

Full description

In this study, cerebral oxygenation and tobacco-related attentional bias in smokers and non-smokers will be measured with magnetic resonance imaging (MRI).

In this study, the oxygen extraction fraction (OEF), the cerebral blood flow (CBF) and the cerebral metabolic rate of oxygen (CMRO2) are to be measured in smokers and non-smokers using MRI. On the one hand, the influence of chronic smoking (i.e. smokers versus non-smokers) and on the other hand the effect of acute nicotine administration (in smokers) on these parameters will be examined. Furthermore, the influence of these parameters on fMRI results is to be investigated using the example of a stimulus-reaction task. It can be assumed that the OEF does not change through nicotine administration, but differs in smokers and non-smokers and is associated with the strength of tobacco addiction in smokers. CBF and CMRO2 are expected to be reduced in abstinent smokers, but can be normalized by nicotine administration. In this study, 20 smokers and 10 never-smokers will be investigated. Never-smokers will be examined once with MRI and questionnaires, whereas smokers will be examined twice: before and after a smoking break.

Enrollment

30 patients

Sex

All

Ages

18 to 65 years old

Volunteers

Accepts Healthy Volunteers

Inclusion criteria

age between 18 and 65
right-handed
normal or correctable eyesight
Sufficient ability to communicate with the investigators, to answer questions in oral and written form
"Fully Informed Consent"
"Written Informed Consent"
Group 1 - Smokers: Occasional smoker or tobacco consumption disorder according to DSM 5
Group 2 - Never-Smokers: Consumption of less than 20 cigarettes in life

Exclusion criteria

women: pregnancy
Withdrawal of the declaration of consent
Exclusion criteria for an MRI scan
severe internal, neurological and psychiatric comorbidities
Pharmacotherapy with psychoactive substances within the last 14 days
Current substance abuse
Axis 1 disorder according to ICD-10 and DSM 5 (except tobacco use disorder and specific phobia within the last 12 months)