Investigation of Clinical Effectiveness of Propolis Extracts as Food Supplements in Patients With SARS-CoV-2(COVID-19)

Trabzon Kanuni Education and Research Hospital

Status: Unknown

Conditions: SARS-CoV2 Infection

Treatments: Dietary Supplement: propolis

Study type: Interventional

Funder types: Other

Identifiers

NCT04916821

00001

Details and patient eligibility

About

Primary purpose: To investigate the effect of propolis, a food supplement product, on healing parameters in patients with COVID 19. Secondary purpose: To provide a new supportive treatment in Covid 19 treatment. In the present study to examine the effect of the use of propolis on healing parameters (laboratory and imaging) in patients with COVID 19; Propolis, which has antiviral properties, has also been used in humans in the COVID19 pandemic as of 2020. However, in these studies, an alcohol-soluble extract of propolis was used. Despite the disadvantages of its use in alcohol, it is clear that water and olive oil extracts of Propolis are safer for humans. Therefore, water extracts of propolis will be used in the study.

Enrollment: 45 estimated patients

Sex: All

Ages: 18 to 59 years old

Volunteers: Accepts Healthy Volunteers

Inclusion criteria

• Patients over the age of 18 who do not need a ventilator who are inpatient in the Covid service
• Patients under the age of 60 who do not need a ventilator who are inpatient in the Covid service

Exclusion criteria

• patients do not have oral intake
• patients whose informed consent form is not approved
• patients who need a ventilator
• pregnant women
• children

Trial design

Primary purpose: Supportive Care

Allocation: Randomized

Interventional model: Parallel Assignment

Masking: None (Open label)

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45 participants in 3 patient groups

water extract of propolis

Experimental group

Description:

Patients given 2 ml of aqueous propolis extract (50mg / ml) orally 3 times a day for 1 week

Treatment:

Dietary Supplement: propolis

olive oil extract of propolis including perga

Experimental group

Description:

Patients given 1 ml oily propolis extract (64 mg / ml) + 1 ml oily perga extract (120 mg / ml) orally 3 times a day for 1 week

Treatment:

Dietary Supplement: propolis

control

No Intervention group

Description:

control group (patients not given any investigational product)