Investigation of Clinical Feature and Brain Function in Narcoleptic Patients

Tang-Du Hospital

Status

Unknown

Conditions

REM Sleep Behavior Disorder

Narcolepsy

Study type

Observational

Funder types

Other

Identifiers

NCT03376568

TDLL-201601-08

Details and patient eligibility

About

This study evaluates the PSG and cerebral metabolism and functions in narcolepsy with/without RBD

Full description

Polysomnographic (PSG) work-up one night to record nocturnal sleep condition in narcolepsy with /without RBD and control subjects including sleep macrostructure, occurrence of sleep onset rapid eye movement period(SOREMP), sleep stages distribution, and sleep arousle and leg movement and apnea hyponea index would be calculated.

Functional magnetic resonance imaging (fMRI) has been used in human to nonivasiverlyn investigate the neural mechanisms. This technique also apply to measures the variations in brain perfusion, structure and morphology in narcolepsy patients by assessing the blood oxygen level-dependent (BOLD) signal diffusion tensor imaging (DTI and voxel-based morphometry(VBM)

This study compare the feature of PSG and fMRI between narcolepsy with RBD, narcolepsy without RBD, control subject to evaluates the PSG and cerebral metabolism and functions in narcolepsy with/without RBD.

Enrollment

100 estimated patients

Sex

All

Ages

10 to 65 years old

Volunteers

Accepts Healthy Volunteers

Inclusion criteria

Narcolepsy meet to the international classification of sleep disorder,3rd edition (ICSD-3) , and RBD meet to the minimal diagnostic criteria according to the international Classification of Sleep, control subjects .

Exclusion criteria

History of heart disease History of central nervous system organic psychosis AHI>15次/h History of alcohol dependence and drug abuse