Investigation of Cognitive Function Before and After Induced Ventricular Fibrillation in Electrophysiological (EP) Study

Heidelberg University

Status: Unknown

Conditions: Ventricular Fibrillation; Ventricular Tachycardia

Treatments: Device: EEG

Study type: Interventional

Funder types: Other

Identifiers

NCT00176176

235/04

Details and patient eligibility

About

In this study, changes in electroencephalogram (EEG) and the hemodynamic state during ventricular fibrillation or induced ventricular tachycardia are investigated.

Full description

Patients with a high risk of malignant tachyarrhythmia are routinely investigated by programmed electrophysiological study (EPS). To investigate the hemodynamic effects of ventricular arrhythmia to cerebral circulation an EEG and transcranial ultrasound are conducted simultaneously during the EPS. Before and after the EPS a neuropsychological test and an investigation of a specific blood sample (Neuron Specific Enolase, NSE) is done.

Sex: All

Ages: 18+ years old

Volunteers: No Healthy Volunteers

Inclusion criteria

• Age > 18 years

• Positive agreement

• EPS for primary and secondary prophylaxis of a malignant ventricular tachyarrhythmia:

  • primary prophylaxis: Brugada syndrome, long QT syndrome, cardiomyopathy, short QT syndrome
  • secondary prophylaxis: Multicenter Automatic Defibrillator Implantation Trial (MADIT) criteria, syncope, documented ventricular tachycardia

Exclusion criteria

• Severe neurological deficit
• Cardiopulmonary resuscitation

Trial design

Primary purpose: Diagnostic

Allocation: Non-Randomized

Interventional model: Single Group Assignment

Masking: None (Open label)