Investigation of Critically Ill Patients With Newly Diagnosed Diabetes

Stamford Hospital

Status: Completed

Conditions: Diabetes Mellitus

Treatments: Diagnostic Test: Diabetes Diagnosis

Study type: Observational

Funder types: Other

Identifiers

NCT05256043

TSH_InternalMedicine_2021010

Details and patient eligibility

About

The purpose of this study is to investigate the clinical outcomes and glucose control metrics of critically ill patients with previously undiagnosed diabetes compared to those with known diabetes at the time of admission to the intensive care unit (ICU).

Full description

This case control study compares previously undiagnosed diabetic patients (defined as HbA1c > 6.5% and no history of diabetes), to those with known diabetes, using 1:1 matching. Patients met inclusion criteria by having HbA1c available on ICU admission and at least four blood glucose tests during their ICU stay. Primary outcomes included ICU length of stay and inpatient mortality. Secondary outcomes included glucose metrics: mean blood glucose, coefficient of variation and percentage of patients who developed hypoglycemia.

Enrollment: 1,777 patients

Sex: All

Ages: 18+ years old

Volunteers: No Healthy Volunteers

Inclusion and exclusion criteria

Inclusion Criteria:20

• Patients admitted between 9/14/2011 and 11/30/19 with HbA1c available on admission and at least four documented blood glucose tests during their ICU stay.

Exclusion Criteria:

• Patients admitted for diabetic ketoacidosis.
• Patients admitted to the ICU following cardiovascular surgery.

Trial design

1,777 participants in 1 patient group

Target Population

Description:

Adult patients age ≥ 18 admitted to the Stamford Hospital ICU between 9/14/11 and 11/30/19 with HbA1c available on admission and at least 4 blood glucose (BG) tests during ICU stay. Two groups were created; patients with previously undiagnosed diabetes (NDDM) compared to those with known diabetes (KDM) at the time of admission to the intensive care unit (ICU).

Treatment:

Diagnostic Test: Diabetes Diagnosis