Investigation of Different Scanning Protocols for 3 Dimensional High-resolution Imaging of the Human Cornea With Optical Coherence Tomography (OCT) - A Pilot Study
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About
The aim of the present study is to develop a protocol for optimal corneal 3-dimensional imaging based on measurements in healthy volunteers. For this purpose, a customized ultra-high resolution Spectral Domain OCT will be used. To validate whether the protocol can also be applied in patients with corneal pathologies, for whom it is intended to be used, measurements in these patients will be performed. We propose to obtain images from patients with keratoconus, since this is one of the most frequent causes for corneal transplantations in Europe and from patients with corneal neovascularization which is a major cause of vision loss in several ophthalmic diseases. Based on the obtained measurement protocol, further studies investigating the pathophysiology or treatment success of several corneal pathologies can be planned.
Enrollment
Sex
Ages
Volunteers
Inclusion criteria
Healthy volunteers:
- Men and women aged over 18 years
- Normal findings in the slit lamp examination, no corneal pathologies
Patients with keratoconus:
- Men and women aged over 18 years
- Presence of keratoconus
- No ophthalmic surgery in the 3 months preceding the study
Patients with corneal neovascularization:
- Men and women aged over 18 years
- Presence of corneal neovascularization
- No ophthalmic surgery in the 3 months preceding the study
Exclusion criteria
- Participation in a clinical trial in the previous 3 weeks
- Presence of any abnormalities preventing reliable measurements as judged by the investigator
- Pregnancy, planned pregnancy or lactating
Trial design
Primary purpose
Allocation
Interventional model
Masking
13 participants in 3 patient groups
Trial contacts and locations
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Data sourced from clinicaltrials.gov
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