Investigation of Effectiveness of Local Antibiotic With Platelet Rich Fibrin on Third Molar Surgery Outcomes In Vivo

Ceren Melahat Donmezer

Status: Completed

Conditions: Impacted Wisdom Tooth; Staphylococcus Aureus; Pain

Treatments: Biological: Platelet Rich Fibrin; Procedure: traditional osteotomies; Drug: Antibiotic; Diagnostic Test: Diagnosis; Drug: Analgesic

Study type: Observational

Funder types: Other

Identifiers

NCT05678296

67-774-2019

Details and patient eligibility

About

The aim of this study was investigate the effectiveness of Local Antibiotic Applications With Platelet Rich Fibrin on Third Molar Surgery Outcomes In Vivo and In Vitro. The study included a total of 60 patients with impacted mandibular third molar. Patients were evaluated in 3 randomly separated groups. For the first and second group, Platelets Rich Fibrin+ local antibiotics were applied into the tooth socket. For the first group, amoxicillin was applied and for the second group, clindamycin was applied. There was a control group which only Platelets Rich Fibrin was applied into the socket. The outcome variables were pain, swelling, the number of analgesics taken, and trismus. These variables were also assessed based on first, second, third, and seventh days following the operation.

Enrollment: 60 patients

Sex: All

Volunteers: Accepts Healthy Volunteers

Inclusion criteria

• patient with no systemic diseases, no current infection, no smoke, no pregnancy

Exclusion criteria

• no inflammation

Trial design

60 participants in 3 patient groups

control group

Description:

platelet-rich fibrin placed into the socket of extracted tooth and no antibiotic is prescribed.

Treatment:

Diagnostic Test: Diagnosis

Biological: Platelet Rich Fibrin

Procedure: traditional osteotomies

Drug: Analgesic

group 1

Description:

platelet-rich fibrin + 0.5 ml amoklavin I.V. 1.2 gr placed into the socket of the extracted tooth.

Treatment:

Diagnostic Test: Diagnosis

Biological: Platelet Rich Fibrin

Procedure: traditional osteotomies

Drug: Antibiotic

Drug: Analgesic

group 2

Description:

platelet-rich fibrin + 0.5 ml Clin 600 mg/4 ml IM/IV, 0.5 ml placed into the socket of the extracted tooth.

Treatment:

Diagnostic Test: Diagnosis

Biological: Platelet Rich Fibrin

Procedure: traditional osteotomies

Drug: Antibiotic

Drug: Analgesic