Investigation of Exercise Training-Induced Myokines and Adipolkines in Humans

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Joslin Diabetes Center

Status

Completed

Conditions

Healthy

Treatments

Other: Exercise Intervention

Study type

Interventional

Funder types

Other
Industry

Identifiers

NCT03037216
2016-34

Details and patient eligibility

About

The purpose of this study is to find out whether exercise training leads to changes in the blood that are produced by exercised muscles and if these changes produce new hormones that affect the body's regulation of sugar and body weight.

Enrollment

10 patients

Sex

All

Ages

18 to 50 years old

Volunteers

Accepts Healthy Volunteers

Inclusion criteria

- Age between 18-35. Body mass index (BMI) must be ≥18.5 and ≤27 kg/m2. HbA1c values ≤5.7%

Exclusion criteria

  • Age <18 and >50
  • HbA1c ≥ 5.7%; heart or lung disease
  • acute systemic infection accompanied by fever, body aches, or swollen lymph glands
  • BMI > 27 kg/m2
  • current dieting or weight loss efforts
  • current pregnancy or breastfeeding
  • known history of HIV/AIDS; cancer
  • biochemical evidence of renal or hepatic dysfunction; renal or liver disease demyelinating diseases such as multiple sclerosis or amyotrophic lateral sclerosis
  • recent blood donation
  • clinical history of stroke
  • hypertension (systolic > 140 mmHg or diastolic > 90 mmHg)
  • type 1 or 2 diabetes; inability to exercise at 50% of predicted heart rate (HR) reserve at baseline
  • Participants taking beta-blockers Participants who screen positive for The American Heart Association's contraindications to exercise testing

Trial design

Primary purpose

Basic Science

Allocation

N/A

Interventional model

Single Group Assignment

Masking

None (Open label)

10 participants in 1 patient group

Experimental Exercise-Training Intervention
Experimental group
Description:
Subjects will undergo a 10-week aerobic exercise protocol.
Treatment:
Other: Exercise Intervention

Trial contacts and locations

1

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Data sourced from clinicaltrials.gov

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