Investigation of Exercise Training-Induced Myokines and Adipolkines in Humans

Joslin Diabetes Center

Status: Completed

Conditions: Healthy

Treatments: Other: Exercise Intervention

Study type: Interventional

Funder types: Other; Industry

Identifiers

NCT03037216

2016-34

Details and patient eligibility

About

The purpose of this study is to find out whether exercise training leads to changes in the blood that are produced by exercised muscles and if these changes produce new hormones that affect the body's regulation of sugar and body weight.

Enrollment: 10 patients

Sex: All

Ages: 18 to 50 years old

Volunteers: Accepts Healthy Volunteers

Inclusion criteria

• Age between 18-35. Body mass index (BMI) must be ≥18.5 and ≤27 kg/m2. HbA1c values ≤5.7%

Exclusion criteria

• Age <18 and >50
• HbA1c ≥ 5.7%; heart or lung disease
• acute systemic infection accompanied by fever, body aches, or swollen lymph glands
• BMI > 27 kg/m2
• current dieting or weight loss efforts
• current pregnancy or breastfeeding
• known history of HIV/AIDS; cancer
• biochemical evidence of renal or hepatic dysfunction; renal or liver disease demyelinating diseases such as multiple sclerosis or amyotrophic lateral sclerosis
• recent blood donation
• clinical history of stroke
• hypertension (systolic > 140 mmHg or diastolic > 90 mmHg)
• type 1 or 2 diabetes; inability to exercise at 50% of predicted heart rate (HR) reserve at baseline
• Participants taking beta-blockers Participants who screen positive for The American Heart Association's contraindications to exercise testing

Trial design

Primary purpose: Basic Science

Allocation: N/A

Interventional model: Single Group Assignment

Masking: None (Open label)

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10 participants in 1 patient group

Experimental Exercise-Training Intervention

Experimental group

Description:

Subjects will undergo a 10-week aerobic exercise protocol.

Treatment:

Other: Exercise Intervention