Investigation of Fat Oxidation During Moderate Versus Vigorous Intensity Exercise (FATOX)

Latvian Institute of Organic Synthesis

Status

Completed

Conditions

Healthy

Sedentary Lifestyle

Treatments

Other: Exercise

Study type

Interventional

Funder types

Other

Identifiers

NCT03864679

Exercise 2018-1

Details and patient eligibility

About

Exercise is widely suggested as an important lifestyle change for weight loss, however, the optimal level of intensity moderate versus vigorous remains unclear. It is known that in athletes, during very high-intensity exercise, fat oxidation is decreased and energy is gained mainly from carbohydrate utilization. The aim of this study is to find an optimal workload based on fat oxidation rate during exercise in volunteers with a sedentary lifestyle.

Full description

It is planned to recruit 12 healthy volunteers with a sedentary lifestyle in the study group. Since different regimens (fed, fasted and moderate versus vigorous) will be compared in the same subjects, no control group is necessary. Subjects will perform a cycling test with 5 min incremental intensity exercise and 1 h cycling test exercising at a moderate-intensity (load will be selected after the incremental intensity exercise). The expiration of carbon dioxide (CO2) and consumption of oxygen (O2) will be measured, to determine the total fatty acid and carbohydrate oxidation during cycling. Concomitantly, it is planned to measure blood lactate and glucose concentrations during exercise experiments as well as a wide range of blood biochemistry parameters before and after exercise.

The investigators expect to find optimal conditions for the sedentary population for burning of fat, which is the major source of energy during moderate-intensity exercise. Measurements of the fat and carbohydrate oxidation in healthy volunteers with a sedentary lifestyle will contribute to the understanding of exercise regimens for the most effective fat oxidation.

Enrollment

12 patients

Sex

All

Ages

20 to 55 years old

Volunteers

Accepts Healthy Volunteers

Inclusion criteria

Healthy
Sedentary lifestyle
BMI 20 - 30 kg/m2
Be able to attend the laboratory and willing to participate in necessary protocols
Be willing to undertake the duration of the exercise protocol (3 x 1 hour)
Have the capacity and willingness to provide informed consent (oral and written)

Exclusion criteria

athletes
Individuals with chronic cardiovascular disease such as hypertension, valve disease, coronary artery disease, cardiac conduction abnormalities, etc.
History of pneumothorax or chronic lung disease such as asthma, COPD, bronchiectasis
Active Smokers
Pregnant women