Investigation of Ferritin in Critically Ill Patients With Hemophagocytic Lymphohistiocytosis (FERRITS)

Gunnar Lachmann

Status: Completed

Conditions: Hemophagocytic Lymphohistiocytosis (HLH); Hemophagocytic Syndromes; Macrophage Activation Syndrome (MAS)

Study type: Observational

Funder types: Other

Identifiers

NCT02854943

HLH

Details and patient eligibility

About

Retrospective analysis of ferritin, outcome and HLH-criteria in critically ill patients.

Full description

The study is a retrospective register study of critically ill patients from Charité - Universitätsmedizin Berlin during 2000 and 2016 that had at least one measurement of plasma ferritin. Outcome, underlying diagnoses and HLH-2004 criteria (Henter JI et al. 2007) will be analyzed and the HScore of these patients will be calculated (Fardet L et al. 2014). All recorded data of the specific admission term in ICU will be used for the analysis. No follow-up of the patients after discharge will be performed in this study. The study does not involve any randomization or any drug testing.

Update 2019: We expanded our database for the years until 2018 and also for the surgical and medical ICUs of the Charité - Universitätsmedizin Berlin (from 256 to 2623 patients).

Update 2022: A systematic literature search will be performed to find suitable validation cohorts for multicenter validation of optimized HLH diagnostic criteria, which are calculated based on our data (new secondary endpoint).

Enrollment: 2,623 patients

Sex: All

Ages: 18+ years old

Volunteers: No Healthy Volunteers

Inclusion criteria

• male and female patients
• at least one measurement of plasma ferritin

Exclusion criteria

-age below 18 years

Trial design

2,623 participants in 1 patient group

Critically ill patients

Description:

Male and female critically ill patients admitted to the Charité - University Medicine Berlin during 2000 and 2018.