Investigation of Genetic Disease Marker Associated With Korean Glaucoma Patients

Chungnam National University

Status: Completed

Conditions: Single-nucleotide Polymorphism (SNP) for Glaucoma

Treatments: Genetic: SNP analysis of the DNA

Study type: Observational

Funder types: Other

Identifiers

NCT01025024

A080587 (Other Grant/Funding Number)

CNUH81510-886

Details and patient eligibility

About

A single-nucleotide polymorphism (SNP) analysis of DNA obtained from peripheral blood of the glaucoma patients and the normal control will be performed to find genetic marker for primary open angle glaucoma.

Full description

Unrelated Korean subjects who have primary open angle glaucoma were recruited in the current study. Genotyping for various SNP associated with POAG due to the linkage disequilibrium patterns is to be performed. Genotypes would be statistically compared between patients with primary open angle glaucoma and normal control subjects free of any eye diseases.

Enrollment: 1,224 patients

Sex: All

Ages: 30+ years old

Volunteers: Accepts Healthy Volunteers

Inclusion criteria

• Clinical diagnosis of primary open angle glaucoma

Exclusion criteria

• Primary open angle glaucoma combined with congenital ocular disease
• Primary open angel glaucoma combined with other ocular disease
• Significant systemic disease other than systemic hypertension and diabetes

Trial design

1,224 participants in 2 patient groups

POAG group

Description:

Elevated intraocular pressure normal open angle glaucomatous optic nerve head abnormality glaucomatous visual field defect

Treatment:

Genetic: SNP analysis of the DNA

Normal control

Description:

Normal intraocular pressure No optic disc abnormality No visual field defect No significant ocular and systemic disease

Treatment:

Genetic: SNP analysis of the DNA