Investigation of Genetic Risk of Atrial Fibrillation

Tokai National Higher Education and Research System

Status: Unknown

Conditions: Atrial Fibrillation

Study type: Observational

Funder types: Other

Identifiers

NCT00412438

RIEM-G-1

Details and patient eligibility

About

The atrial fibrillation (AF) is the most common cardiac rhythm disturbance that is responsible for substantial morbidity and mortality independent of associated heart disease or other risk factors. Even in the absence of preexisting cardiovascular disease, AF remains significantly associated with excess mortality rates. The current unsatisfactory treatment for AF comes from lack of understanding of the pathophysiology of AF. The purpose of this study is to identify gene polymorphisms that confer susceptibility to atrial fibrillation. Patients with AF（N=500） and healthy volunteer（N=1000） without AF are enrolled in this study. Patients with coronary artery disease, severe valvular heart disease, cardiomyopathy or heart failure were excluded from the study.

Sex: All

Volunteers: Accepts Healthy Volunteers

Inclusion criteria

• Clinical diagnosis of atrial fibirillation

Exclusion criteria

• coronary artery disease
• severe valvular heart disease
• cardiomyopathy
• heart failure