Investigation of Genetic Risk of Cardiovascular Disease in Prospective Cohort Study

Tokai National Higher Education and Research System

Status: Unknown

Conditions: Cerebral Infarction; Healthy; Myocardial Infarction; Coronary Disease

Study type: Observational

Funder types: Other

Identifiers

NCT00262691

NU-05-G-0001

Details and patient eligibility

About

Cardiovascular disease is a complex multifactorial and polygenic disorder that is thought to result from an interaction between a person's genetic make up and various environmental factors. Although many studies have revealed that several genetic variants increase the risk of cardiovascular disease, the results of these studies remain controversial. The purpose of this study is to identify polymorphisms that confer susceptibility to cardiovascular disease and to clarify the adequacy of reported susceptibility gene polymorphisms. To complete this purpose, we will prospectively study over 5,000 local residents in whom relationship between these polymorphisms and occurrence of cardiovascular disease over 5 years.

Enrollment: 7,000 estimated patients

Sex: All

Ages: 50+ years old

Volunteers: No Healthy Volunteers

Inclusion and exclusion criteria

Inclusion Criteria:

• Healthy subjects who undergo community-based annual health check in Kitanagoya city