Investigation of Hemodynamics and Radiomics Based on High Resolution Magnetic Resonance Imaging for Predicting the Outcomes of Intracranial Dissecting Aneurysm

Beijing Neurosurgical Institute

Status: Active, not recruiting

Conditions: Intracranial Arterial Dissection; Cerebrovascular Disease; Intracranial Aneurysm

Study type: Observational

Funder types: Other

Identifiers

NCT07335029

KY2024-315-02

Details and patient eligibility

About

This study aims to conduct a comprehensive analysis by integrating clinical factors, aneurysm morphological characteristics, and factors reflecting pathophysiological processes (such as hemodynamic and radiomics features), in order to explore the hemodynamic mechanisms associated with the progression of intracranial dissecting aneurysms. Furthermore, artificial intelligence algorithms will be employed to develop and validate an intelligent risk prediction model for the progression and outcomes of intracranial dissecting aneurysms.

Enrollment: 208 estimated patients

Sex: All

Ages: 18 to 80 years old

Volunteers: No Healthy Volunteers

Inclusion criteria

1. Intracranial dissecting aneurysm clearly diagnosed by DSA and high-resolution MRI imaging (according to the imaging diagnostic criteria proposed in the Chinese Expert Consensus on Imaging Diagnosis of Intracranial Arterial Dissection)
2. patients managed with conservative treatment and follow-up
3. patients who agree and sign a written informed consent form

Exclusion criteria

1. Arteritis, fibromuscular dysplasia, iatrogenic or traumatic pseudoaneurysms
2. Contraindications to MRI examination (such as claustrophobia or metallic implants), or contraindications to cerebral angiography (such as iodine contrast allergy)
3. Dissecting aneurysms extending from the extracranial segment to the intracranial segment, or cases with concomitant intracranial atherosclerotic plaques in the affected vessels
4. Patients who refuse MRI examination
5. Patients with severe comorbid diseases and an expected survival time of less than 2 years due to these conditions
6. Patients without follow-up HR-MRI imaging for any reason

Trial design

208 participants in 2 patient groups

Control Group (Non-progression Group)

Description:

Imaging progression of intracranial dissecting aneurysms during follow-up

Experimental Group (Progression Group)

Description:

Imaging progression of intracranial dissecting aneurysms during follow-up