Investigation of Low-intensity Focused Ultrasound for Human Pain Management

Virginia Polytechnic Institute and State University

Status

Invitation-only

Conditions

Chronic Pain

Treatments

Device: Low Intensity Focused Ultrasound

Study type

Interventional

Funder types

Other

Identifiers

NCT05145426

21-796

Details and patient eligibility

About

This project examines the effects of noninvasive brain stimulation on pain. The investigators believe this study will help to better understand possible treatments for chronic pain patients. Participants undergo structural imaging, a functional Magnetic Resonance Image (fMRI) and computed tomography (CT). These images are used to align the low-intensity focused ultrasound (LIFU) device which uses sound waves to temporarily change brain activity. Pain testing is done using a small device that will increase/decrease the temperature of the skin. Brain signals are collected using electroencephalography (EEG). Heart rate, blood pressure, and skin moisture will be monitored as well.

Enrollment

80 estimated patients

Sex

All

Ages

18 to 65 years old

Volunteers

Accepts Healthy Volunteers

Inclusion criteria

Understand and speak English

Exclusion criteria

MRI/CT/EEG contraindications.
1. Claustrophobia
2. Contraindications to MRI: including pacemaker, aneurysm clips, neurostimulators, cochlear implants, metal in eyes, steel worker, or other implants.
3. Contraindications to CT: pregnancy
4. Active medical disorder or treatment with potential CNS effects
5. History of neurologic disorder
6. History of head injury resulting in loss of consciousness for >10 minutes.
7. History of alcohol or drug dependence
8. Failure to provide Social Security Number or Tax ID number. This is required for tax purposes or payment cannot be processed.