Investigation of Low-intensity Focused Ultrasound Parameters

Virginia Polytechnic Institute and State University

Status

Completed

Conditions

Development of LIFU for Clinical Purposes

Treatments

Device: Low-intensity Focused Ultrasound

Study type

Interventional

Funder types

Other

Identifiers

NCT05134233

21-882

Details and patient eligibility

About

This project examines the effects of different brain stimulation settings on muscle contractions. The investigators believe this study will help to better understand noninvasive brain stimulation techniques that may have the potential to aid in addiction, pain, and mental health issues. Participants undergo structural imaging, an fMRI and CT. These images are used to align the low-intensity focused ultrasound (LIFU) and transcranial magnetic stimulation (TMS) devices to temporarily change brain activity. Electromyography (EMG) will be used to record muscle contractions on the hand.

Enrollment

23 patients

Sex

All

Ages

18 to 65 years old

Volunteers

Accepts Healthy Volunteers

Inclusion criteria

Above criteria and must understand and speak English.

Exclusion criteria

Contraindications to MRI, CT, or TMS
1. Claustrophobia
2. Pacemaker, aneurysm clips, neurostimulators, cochlear implants, metal in eyes, steel worker, or other implants.
3. Pregnancy
4. Active medical disorder or treatment with potential CNS effects
5. History of neurologic disorder
6. History of head injury resulting in loss of consciousness for >10 minutes
7. History of alcohol or drug dependence
8. Failure to provide a social security number or tax ID number. This is required for tax purposes or payment cannot be processed.