Investigation of MP Pollution in the Human Respiratory System and Its Relationship to Lung Cancer

H. Lee Moffitt Cancer Center and Research Institute

Status: Active, not recruiting

Conditions: Lung Cancer

Treatments: Procedure: Bronchoalveolar Lavage (BAL) during Bronchoscopy

Study type: Observational

Funder types: Other

Identifiers

NCT06530615

MCC-22605

Details and patient eligibility

About

This project will study and characterize Microplastic (MP) burden in the lungs of patients undergoing Bronchoalveolar Levage (BAL) in thoracic clinics at Moffitt.

Enrollment: 119 patients

Sex: All

Ages: 18+ years old

Volunteers: No Healthy Volunteers

Inclusion criteria

• English or Spanish-speaking patients scheduled for bronchoscopy/bronchoalveolar lavage (BAL) in thoracic clinics at Moffitt.

Exclusion criteria

• Patients with a known prior history of lung cancer or that have undergone a Bronchoalveolar Lavage (BAL) procedure at any time in the past in the involved lung targeted for BAL.
• Patients that have had any prior lung or thoracic or surgeries or procedures (examples: removal of lung or portions of the involved lung (lobectomy, pneumonectomy, wedge resection/segmentectomy).
• Patients with specimens that are considered to be non-adequate as true Bronchoalveolar Lavage Fluid (BALF) (i.e., absence of alveolar macrophages) after pathologist's evaluation will be excluded from the study.

Trial design

119 participants in 2 patient groups

Lung Neoplasm

Description:

Lung Cancer cases will be comprised of patients that are confirmed to have lung cancer based on bronchoscopy/ Bronchoalveolar Lavage (BAL) and other clinical testing.

Treatment:

Procedure: Bronchoalveolar Lavage (BAL) during Bronchoscopy

Lung Neoplasm Excluded

Description:

Lung Cancer excluded cases will be comprised of the remaining patients in whom lung cancer is excluded as a diagnosis based on bronchoscopy/ Bronchoalveolar Lavage (BAL) and other clinical testing.

Treatment:

Procedure: Bronchoalveolar Lavage (BAL) during Bronchoscopy