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Investigation of Oxidative Markers and Antioxidant Defense in Female Patients With Osteoarthritis

I

Iuliu Hatieganu University of Medicine and Pharmacy

Status

Unknown

Conditions

Osteoarthritis

Treatments

Other: Questionnaire of eating habits

Study type

Observational

Funder types

Other

Identifiers

NCT04206462
UniversitateaIH

Details and patient eligibility

About

Osteoarthritis has a multifactorial etiology: aging, genetic, sex, weight, alimentation, injuries, infections etc. The objective of the study is to investigate the eating behaviour of the patients included in the study by using a semiquantitative questionnaire (frequency and quantity) by estimating the foods that are known to be protective for osteoarthritis (vegetables, fruits, cereals) as the ones that are considered risk factors (meat origin, refined fats). Also, the oxidative-antioxidative balance will be evaluated by determining markers: oxidated glutathione/reducted glutathione, catalase enzyme, superoxide dismutase, glutathion peroxidase and malonyldialdehyde.

Full description

A total of 300 patients with osteoarthritis will be included in the study. The objective of the study is to investigate the eating behaviour of the patients included in the study by using a semiquantitative questionnaire (frequency and quantity) by estimating the foods that are known to be protective for osteoarthritis (vegetables, fruits, cereals) as the ones that are considered risk factors (meat origin, refined fats). Also, the weight and height of each patient will be assessed and the patients will be included in 4 classes based on the body mass index: underweight, normal weight, overweight and obese. The type of physical activity will also be noted and the oxidative-antioxidative balance will be evaluated by determining serum markers: oxidated glutathione/reducted glutathione, catalase enzyme, superoxide dismutase, glutathion peroxidase and malonyldialdehyde. Correlation between eating behaviour, body mass index and oxidative stress markers will be made.

Enrollment

300 estimated patients

Sex

Female

Volunteers

No Healthy Volunteers

Inclusion criteria

  • osteoarthritis
  • signed informed consent

Exclusion criteria

  • drugs or foods with antioxidant effects
  • lack of judgement
  • refuse to participate

Trial design

300 participants in 1 patient group

Osteoarthritis
Description:
Questionnaire of eating habits, markers of oxidative stress
Treatment:
Other: Questionnaire of eating habits

Trial contacts and locations

1

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Central trial contact

Rodica A Ungur, MD, PhD

Data sourced from clinicaltrials.gov

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