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Investigation of Platelet Function and Aspirin Resistance in Chronic Dialysis Patient

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National Taiwan University

Status

Unknown

Conditions

End Stage Renal Disease

Study type

Observational

Funder types

Other

Identifiers

NCT01045785
200912018R

Details and patient eligibility

About

The purpose of this study is to determine whether aspirin resistance has impact on cardiovascular event in dialysis patient.

Full description

Dialysis patient inevitably suffered from uremic bleeding although improvement of dialysis care in the past decades. Physicians used to check bleeding time as a surrogate marker for uremic bleeding. However, bleeding time isn't accurate and as well known, is poorly correlated with clinical bleeding such as surgical bleeding. Platelet function assay (PFA) is a newly developed method to measure platelet aggregation in vitro and is validated in many sorts of platelet disorders. Recently, PFA was also used to evaluate aspirin responsiveness in patients who had taken aspirin. Our study is aim to investigate uremic thrombocytopathy via PFA of dialysis patient in Taiwan. Furthermore, we will study aspirin resistance in dialysis patient.

Enrollment

300 estimated patients

Sex

All

Ages

20+ years old

Volunteers

Accepts Healthy Volunteers

Inclusion criteria

  • dialysis >3 months
  • Hb>10 g/dl & Plt > 10000

Exclusion criteria

  • using medication which interfere PFA except aspirin
  • terminal disease such as malignancy
  • active vasculitis

Trial design

300 participants in 2 patient groups

aspirin responsive
Description:
PFA Col/EPI normal
aspirin resistance
Description:
PFA Col/epi showed resistance

Trial contacts and locations

1

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Data sourced from clinicaltrials.gov

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