Investigation of Safety, Pharmacokinetics and Pharmacodynamics of Different Doses of BIWH 3 in Patients With Chronic Critical Limb Ischaemia (COINART-1)

Boehringer Ingelheim

Status and phase

Terminated

Phase 1

Conditions

Peripheral Arterial Disease

Treatments

Drug: BIWH 3

Drug: Placebo

Study type

Interventional

Funder types

Industry

Identifiers

NCT02215824

1181.1

Details and patient eligibility

About

The primary aim of this trial was to investigate the safety of a 6 hour intraarterial infusion of BIWH 3 (pyro-Glu-rhMCP-1) in patients with severe peripheral arterial occlusive disease (PAOD) and chronic Critical Limb Ischaemia (Fontaine class III or IV).

Enrollment

7 patients

Sex

All

Ages

18+ years old

Volunteers

No Healthy Volunteers

Inclusion and exclusion criteria

Inclusion:

Patient must have severe PAOD with Chronic Critical Limb Ischaemia, Fontaine class III (ischaemic pain at rest) or IV (tissue ulceration or gangrene) due to atherosclerotic disease
Patient must be >= 18 years of age
Patient must give written informed consent
Patient must have a life expectancy of at least six months

Exclusion:

Transient ischaemic attack (TIA), cerebral vascular accident (CVA), myocardial infarction (MI) or episode of unstable angina within the past two months
Ophthalmologic conditions: moderate to severe nonproliferative retinopathy, proliferative retinopathy, age related maculopathy with choroidal neovascularisation, macular edema, intraocular surgery within the previous 6 months, retinal vein occlusion
Presence of a clinically significant disease which in the opinion of the investigator may either put the patient at risk because of participation in the study or a disease which may influence the result of the study or the patient's ability to participate in the study
ECG results outside of the reference range of clinical relevance including, but not limited to QTcB > 480 msec, PR interval > 240 msec, QRS interval > 140 msec
History of malignant disease, or a positive result on any of the required cancer screening tests, unless a definitive subsequent evaluation for cancer is determined to be negative
Patients at increased risk of colorectal cancer, including any of the following (1) colorectal cancer pr polyps in a first-degree relative younger than 60 or in two first-degree relatives of any age, (2) family history of familial adenomatous polyposis or hereditary non-polyposis colon cancer, (3) history of adenomatous polyps, or (4) history of chronic inflammatory bowel disease (chronic ulcerative colitis or Crohn's disease)
Abnormalities greater than two times the upper limit of normal in any of the following laboratory values at Visit 1: alanine-aminotransferase (ALT), aspartate-aminotransferase (AST), gamma-glutamyl transferase (GGT), alkaline phosphatase or lactic dehydrogenase (LDH); abnormalities greater than 1.5 times the upper limit of normal of total bilirubin or white blood cell count
Any concurrent infectious disease requiring treatment
Severe renal insufficiency (estimated creatinine clearance < 30 mL/min)
Duffy antigen negative blood type with co-existing moderate to severe renal insufficiency (estimated creatinine clearance < 80 mL/min), to avoid potential risk of significant increase of monocyte chemoattractant protein-1 (MCP-1) levels
Known glomerulonephritis, even if creatinine clearance is apparently normal
Thrombocytopenia, i.e. platelet count <100,000 cells/μl at Visit 1
History of drug or alcohol abuse within the past 2 two years or active drug or alcohol abuse, present alcohol intake more than three drinks per day
Inability to comply with the protocol
Treatment with an investigational drug within 30 days or 5 half-lives, whichever is greater before Visit 2
Use of cilostazol if cilostazol therapy was started within 2 months prior to trial enrollment, or planned initiation of cilostazol therapy during the trial period. Patients who have been on cilostazol for > 2 months prior to enrollment may be enrolled
Inability to discontinue the intake of coumadin until after completion of the treatment period. Patients who were on coumadin must have an international normalised ratio (INR) < 1.8 at Visit 2
Previous enrollment in this trial
Hypersensitivity or allergy to heparin, conventional angiographic contrast dye, or magnetic resonance angiography (MRA) contrast
Inability to undergo MRA (e.g. heart pacemaker, artificial heart valve, implanted neurostimulator, intrauterine device (IUD), metallic ear implant, implanted port for delivering insulin, or other foreign or implanted or metallic objects such as bullet fragments, metal plates, pins, screws or staples, joint replacement, or penile implant)
Know HIV-infection
Unwillingness to take blood products
Pregnancy (to be excluded by serum and urine beta-human chorionic gonadotropin-test in women of childbearing potential) or breast feeding
Female of childbearing potential (not 12 months post-menopausal or surgically sterilized) not using one of the following methods of birth control: hormonal contraceptives, oral or injectable/implantable