Investigation of Specific Protein/Markers in Patients With Osteoarthritis of the Knee Having a Total Knee Replacement

AstraZeneca

Status: Completed

Conditions: Osteoarthritis of the Knee

Study type: Observational

Funder types: Industry

Identifiers

NCT01611441

D2285M00029

Details and patient eligibility

About

The main purpose of the study is to better understand how specific proteins/markers in blood, urine, synovial fluid (a lubricating fluid secreted by the membrane lining the joints), and joint tissue are involved in osteoarthritis of the knee. The aim is to investigate if there is a correlation between x-ray results, specific proteins/markers and different types of pain in patients with osteoarthritis of the knee. The study consists of 3 visits over 3-20 days and the last visit will be the day of surgery.

Full description

Investigation of Biomarkers in an Exploratory Study in Patients with Osteoarthritis of the Knee Undergoing Total Knee Replacement Surgery

Enrollment: 125 patients

Sex: All

Ages: 40+ years old

Volunteers: No Healthy Volunteers

Inclusion criteria

• Patients who will undergo a total knee replacement due to osteoarthritis.
• Symptoms of the knee for at least 6 months prior to study start.

Exclusion criteria

• Key-hole surgery performed on target knee within 3 months prior to study start.
• History of disorders in which part of the immune system is missing or defective.

Trial design

125 participants in 1 patient group

Patients with osteoarthritis of the knee

Description:

Patients with osteoarthritis of the knee undergoing total knee replacement surgery.