Investigation of the Effect of 8-week Controlled High Intense Interval Training in Type 2 Diabetic Patients (DIATRAIN)

Aarhus University Hospital

Status: Completed

Conditions: Type 2 Diabetes

Treatments: Other: Physical training

Study type: Interventional

Funder types: Other

Identifiers

NCT02333734

T2D-training

Aarhus University (Other Grant/Funding Number)

Details and patient eligibility

About

The overall objective of this study is to examine the blood flow in the thigh muscles and sugar metabolism before and after 8 weeks of high intensity interval training (HIIT) on a bicycle ergometer in patients with type 2 diabetes (T2D) and matched controls. The following parameters are included in the assessment:

• Sugar Metabolism
• Muscle and fat mass
• The blood flow at rest around the thigh muscles
• Oxygen uptake test on a bicycle ergometer and 5 km time trial

Full description

Type 2 diabetes (T2D) can be defined as a bihormonal metabolic disorder characterised by insufficient insulin secretion and abnormal glucagon secretion. It is however well established that physical activity per se improves glucose and may postpone or even slow down in the diabetic population. Glycaemic control may be improved more by high intensity interval training than by intensities from existing recommended guidelines. Additionally, there seems to be accumulating evidence that high intensity interval training induces increased overall fat and abdominal fat mass loss as opposed to traditional continuous endurance training Therefore we hypothesise that 3 weekly sessions of high intensity interval training (10×60 sec. at an intensity inducing 90% of maximal heart frequency with a recovery of 60 sec. between each bout) over 8 weeks improves overall glycaemic control (glucose, insulin and glucagon), inflammatory status (interleukins, cytokines, chemokines and cell adhesion molecules) and blood flow (NO and PGI2 vasodilatory capabilities).

Enrollment: 23 patients

Sex: All

Ages: 40 to 65 years old

Volunteers: Accepts Healthy Volunteers

Inclusion criteria

• Type 2 diabetes or matched healthy controls. T2D subject only : HbA1c > 7,3. All subjects have an age between 40-65 years and a body mass index between 25-40 kg/m2. Both genders is allowed

Exclusion criteria

• Severe diseases /immobility

Trial design

Primary purpose: Basic Science

Allocation: Randomized

Interventional model: Parallel Assignment

Masking: None (Open label)

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23 participants in 2 patient groups

Type 2 diabetic subjects

Experimental group

Description:

Type 2 diabetic subjects physical training (interval training 3 times at week) in a period of 8 weeks.

Treatment:

Other: Physical training

Healthy subjects

Experimental group

Description:

Healthy subjects physical training (interval training 3 times at week) in a period of 8 weeks.

Treatment:

Other: Physical training