Investigation of the Effects of H-PRF on the Period After Impacted Third Molar Tooth Extraction

esengul sen

Status: Completed

Conditions: Impacted Third Molar Tooth

Treatments: Procedure: Impacted Tooth Removal; Procedure: L-PRF and H-PRF

Study type: Interventional

Funder types: Other

Identifiers

NCT06244797

23-KAEK-146

Details and patient eligibility

About

After wisdom teeth are extracted, the patient may have some complaints in the post-operative period. Pain, swelling and edema are some of them. These inflammatory complications are important for patients and surgeons to reduce the risk of complications and ensure postoperative recovery and develop customized strategy. Many studies have been conducted in the literature to minimize these situations encountered after tooth extraction.

Full description

Many studies have been conducted in the literature to minimize these situations encountered after tooth extraction. Various regenerative methods are being developed to reduce these complaints of patients. Regenerative treatments include non-steroidal anti-inflammatory drugs (NSAIDs), laser therapy, steroids, ultrasound, and PRF applications.

PRF(platelet-rich fibrin) application placed in the extraction socket is one of the regenerative methods used to reduce these complaints. PRF has a fibrin structure obtained from natural blood tissue, containing abundant platelets and leukocytes. This fibrin matrix contains various growth factors and cytokines, including growth factor-beta1 (TGF-β1), platelet-derived growth factor (PDGF), vascular endothelial growth factor (VEGF), interleukin (IL), as well as platelets and leukocytes. These factors act directly on promoting the proliferation and differentiation of osteoblasts, endothelial cells, chondrocytes, and various fibroblast sources.

It is known that PRF has a beneficial effect in relieving pain and swelling and reducing the incidence of alveolar osteitis after extraction of an impacted lower third molar. Therefore, it is placed in extraction sockets to try to reduce post-operative complications.

PRF applications are also developing in their own right, and one of them is the H-PRF (horizontal PRF) application. Recently, horizontal centrifugation of PRF has been shown to provide better cell layer separation and minimize cell accumulation that prevents uniform cell layer formation on the distal surfaces of centrifuge tubes.

Enrollment: 75 patients

Sex: All

Ages: 18 to 40 years old

Volunteers: Accepts Healthy Volunteers

Inclusion criteria

• Volunteer ASA I individuals between the ages of 18-40

Exclusion criteria

• Those who are pregnant or lactating
• Those receiving anticoagulant or antiplatelet drug therapy
• Those who received radiotherapy to the head and face area
• Those who are allergic to local anesthetics and prescribed medications

Trial design

Primary purpose: Supportive Care

Allocation: Randomized

Interventional model: Parallel Assignment

Masking: Single Blind

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75 participants in 3 patient groups, including a placebo group

CONTROL GROUP

Placebo Comparator group

Description:

Patient group in which no material is placed in the extraction socket after impacted tooth extraction. There will be 25 patients in this group.

Treatment:

Procedure: L-PRF and H-PRF

Procedure: Impacted Tooth Removal

L-PRF (leukocyte-platelet rich fibrin):

Active Comparator group

Description:

The patient group in which L-PRF will be placed in the extraction socket after impacted tooth extraction. There will be 25 patients in this group. Device information to be used: Electromag M815P centrifuge device.

Treatment:

Procedure: L-PRF and H-PRF

Procedure: Impacted Tooth Removal

H-PRF (horizontal-platelet rich fibrin)

Active Comparator group

Description:

The patient group in which H-PRF will be placed in the extraction socket after impacted tooth extraction. There will be 25 patients in this group. Device information to be used: Electromag M815A2 centrifuge device.

Treatment:

Procedure: L-PRF and H-PRF

Procedure: Impacted Tooth Removal