Investigation of the Effects of Pilates Training in Patients With Drug-Resistant Epilepsy

Recep Tayyip Erdogan University Training and Research Hospital

Status: Completed

Conditions: Seizures; Epilepsy; Quality of Life; Cognitive Dysfunction; Depression; Sleep

Treatments: Other: Control Group; Other: Pilates Group

Study type: Interventional

Funder types: Other

Identifiers

NCT06754124

2024/10

Details and patient eligibility

About

This study was planned to examine the effects of Pilates training in patients with drug-resistant epilepsy. It was planned to include 40 epilepsy patients in the study. The control group was planned to continue routine drug treatment for 8 weeks. The Pilates group was planned to receive Pilates training 3 days a week for 8 weeks in addition to routine drug treatment. It was aimed to examine the effects of Pilates training performed 3 times a week for 8 weeks on seizure frequency, core stability, balance, functional exercise capacity, cognitive functions, dual task, fatigue, kinesiophobia, sleep quality, depression and quality of life in patients with drug-resistant epilepsy.

Full description

This study was planned to investigate the effects of Pilates training, a "core" stability-based exercise method that improves body alignment, postural control, and balance in patients with drug-resistant epilepsy, on seizure frequency, core stability, balance, functional exercise capacity, cognitive functions, dual task, fatigue, kinesiophobia, sleep quality, depression, and quality of life. It was planned to include 40 epilepsy patients in the study. The patients were planned to be randomly divided into two groups as Pilates (n: 20) and control (n: 20). The control group was planned to continue routine drug treatment for 8 weeks. The Pilates group was planned to receive Pilates training 3 days a week for 8 weeks in addition to routine drug treatment. Seizure frequency with the seizure diary; the "core" power with the "sit-ups" and the modified "push-ups" tests; the "core" endurans with the lateral bridge, the trunk flexor endurance, the prone bridge and the modified "Biering-Sorensen" tests; balance with the Balance Error Scoring System (BESS) and the Four-Step Square Test (FSTT); functional exercise capacity with the 6-Minute Walk Test (6-MWT); functional mobility and dual task with the Timed Up and Go Test (TUG); cognitive functions with the BILNOT battery; fatigue with the Fatigue Severity Scale (FSS); kinesiophobia with the Tampa Kinesiophobia Scale; sleep quality with the Pittsburgh Sleep Quality Index (PSQI); depression with the Neurological Disorders Depression Inventory in Epilepsy (NDDI); and health-related quality of life with the Quality of Life in Epilepsy Scale (QOLIE-31) were evaluated before and after treatment.

Enrollment: 30 patients

Sex: All

Ages: 18 to 65 years old

Volunteers: No Healthy Volunteers

Inclusion criteria

• Being between the ages of 18-65
• Being diagnosed with idiopathic refractory epilepsy by a specialist neurologist
• Not having had status epilepticus for 1 year before the study
• Being able to walk independently
• Not having participated in a regular exercise program
• Having a Standardized Mini Mental Test score greater than 24
• Antiepileptic drug doses being stable during the study

Exclusion criteria

• History of any diagnosed neurological or neuropsychiatric disease other than epilepsy
• Presence of any cardiovascular, pulmonary, orthopedic or other medical conditions that would limit participation in the study
• Pregnancy and breastfeeding

Trial design

Primary purpose: Treatment

Allocation: Randomized

Interventional model: Crossover Assignment

Masking: Double Blind

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30 participants in 13 patient groups

Pilates Group

Experimental group

Description:

Pilates training will be given individually for approximately 1 hour, 3 days a week for 8 weeks.

Treatment:

Other: Pilates Group

Control Group

Active Comparator group

Description:

Routine medication will be continued for 8 weeks.

Treatment:

Other: Control Group

Evaluation of seizure frequency

No Intervention group

Description:

Seizure frequency will be calculated based on the patient's diary in the 2 months prior to the assessment. Patients without a seizure diary will be given one and asked to record their seizures for 2 months.

Evaluation of core stability

No Intervention group

Description:

"Core" stability was evaluated with two important dimensions, "core" strength and endurance tests.

Evaluation of balance

No Intervention group

Description:

Balance will be assessed separately with static and dynamic balance tests. The Balance Error Scoring System test will be used to assess static balance, and the Four-Step Square Test will be used to assess dynamic balance.

Evaluation of Functional Exercise Capacity

No Intervention group

Description:

Functional exercise capacity was evaluated using the 6 Minute Walking Test (6-MWT).

Evaluation of cognitive function

No Intervention group

Description:

Cognitive function will be assessed with the Standardized Mini Mental State Examination and the Neuropsychological Test Battery for Cognitive Potentials.

Evaluation of dual task

No Intervention group

Description:

Dual task will be evaluated by adding a second task to the Timed Up and Go Test (TUG).

Evaluation of fatigue

No Intervention group

Description:

Fatigue will be assessed using the Fatigue Severity Scale (FSS).

Evaluation of kinesiophobia

No Intervention group

Description:

Kinesiophobia will be assessed with the Tampa Kinesiophobia Scale (TKS).

Evaluation of sleep quality

No Intervention group

Description:

Sleep quality will be assessed by the Pittsburgh Sleep Quality Index (PSQI).

Evaluation of depression

No Intervention group

Description:

The Inventory of Neurological Disorders Depression in Epilepsy will be used to assess depression.

Evaluation of quality of life

No Intervention group

Description:

Quality of Life In Epilepsy (QOLIE-31) will be used to determine health-related quality of life in epilepsy.