Investigation of the Effects of Sedentary Behaviour and Moderate Exercise on Glucose Tolerance and Insulin Sensitivity

University of Prince Edward Island

Status: Terminated

Conditions: Sedentary Lifestyle; Glucose Metabolism; Insulin Sensitivity

Treatments: Other: Activity/Moderate Exercise

Study type: Interventional

Funder types: Other

Identifiers

NCT03827239

6007895

Details and patient eligibility

About

Individuals with pre-diabetes or diabetes would benefit from low impact methods that would improve their insulin sensitivity and aid in maintaining glucose homeostasis. Physical activity helps the body decrease its insulin resistance and burn excess sugar. Many diabetics also suffer from obesity and specific forms or durations of physical exercise may not be viable options for these individuals. Determining whether short bursts of moderate exercise improve blood glucose levels in healthy humans may identify a further method for diabetics to improve their glucose homeostasis.

The aim of this study is to determine the most effective moderate exercise that can be completed in 3 minutes and its effectiveness on improving glucose handling, in response to a single day of standardized high-fat and high-carbohydrate feeding in comparison to periods of prolonged sitting.

Enrollment: 6 patients

Sex: All

Ages: 18 to 50 years old

Volunteers: Accepts Healthy Volunteers

Inclusion criteria

• healthy
• BMI between 18-30 kg/m²
• non-smoker

Exclusion criteria

• pregnant
• diabetes
• kidney disease
• liver disease
• cardiovascular disease
• cancer

Trial design

Primary purpose: Prevention

Allocation: Randomized

Interventional model: Crossover Assignment

Masking: None (Open label)

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6 participants in 2 patient groups

Control

No Intervention group

Description:

No intervention. Study participants will be seated during the entire sedentary 3-hour time period and wheeled to phlebotomy (and exercise) stations when required. During the sedentary period, participants will eat the food according to the study protocol and be seated at desks and allowed to read and use computers.

Intervention

Experimental group

Description:

Will disrupt their sedentary time with 3 minute exercise sessions every 30 minutes

Treatment:

Other: Activity/Moderate Exercise