Investigation of the Glycemic Index of Ethiopian Honey

Addis Ababa University

Status and phase

Completed

Early Phase 1

Conditions

Hyperglycemia, Postprandial

Treatments

Biological: Provision of experimental honey

Study type

Interventional

Funder types

Other

Identifiers

NCT02488018

Honey-1

Details and patient eligibility

About

The purpose of this study is to determine which of the Ethiopian honeys slowly/rapidly raise the blood glucose level.

Full description

Addis Ababa University, College of Natural Sciences, Research Institutional Review Board (IRB) approved this study. Written consent forms were obtained from all 14 volunteers (7 females and 7 males). The subjects were randomly recruited from twenty eight 3rd year Food Science and Postharvest Technology students. People volunteering to participate in the study were excluded if they are: overweight, dieting, smoking, a family history of diabetes, pregnant, metabolic disorders, suffering from any illness or food allergy and regularly taking medication. The participants were checked for glucose tolerance according to the WHO (World Health Organization) classification (fasting glucose <7 mmol/L(millimole per lite) and 2-hour blood glucose concentration after a 25g glucose load <7.8 mmol/L). Ten (5 females and 5 males) were selected from fourteen using lottery sampling methods. Reference glucose and monofloral honeys were used as experimental foods. To determine the GI value, 25 grams of available carbohydrate was fed for ten healthy people in the morning after they have fasted for 11 hours overnight. After fasting blood sample was obtained. The study participants were consumed each honey and reference glucose served. Additional blood samples were taken at 15, 30, 45, 60, 90 and 120 minutes after eating commenced. Blood glucose response (Area under the curve, AUCt) for test food was compared to the blood glucose response of reference glucose (AUCr). AUC was calculated using SAS (Statistical Analysis Software), 2002. Glycemic index (GI) was calculated using:

GI= AUCt/AUCr*100

Where:

AUCt = Area Under the Curve for honey; AUCr = Area Under the Curve for the reference glucose

Enrollment

10 patients

Sex

All

Ages

20 to 24 years old

Volunteers

Accepts Healthy Volunteers

Inclusion criteria

Clinical diagnosis of diabetes Disease
Must be able to drink the honeys and reference glucose

Exclusion criteria

Overweight, dieting, smoking, a family history of diabetes, pregnant, metabolic disorders, suffering from any illness or food allergy and regularly taking medication.