Investigation of the Immuno-regulation and Viral Hepatitis Among Patients With or After Dengue Fever Infection

Kaohsiung Medical University

Status: Unknown

Conditions: Dengue Fever

Treatments: Other: case/control

Study type: Observational

Funder types: Other; Other U.S. Federal agency

Identifiers

NCT00688389

KMUH-IRB-960195_1

CB9615

Details and patient eligibility

About

The study will collect the blood samples from 350 healthy persons and 350 persons infected with dengue fever.

Full description

Research has showed that CLEC5A interacts with dengue virion directly, and is responsible for dengue virus (DV)-induced DAP12 phosphorylation. Data suggests that CLEC5A is a potential therapeutic target for dengue hemorrhagic fever (DHF)/dengue shock syndrome (DSS). This project will study the genes of CLEC5A, Mannose receptor, DC-SIGN, NALP, decoy receptor 3 (DcR3), Toll-like receptors(TLRs), and (Nod)-like receptors (NLRs) for both DF and DHF groups. In addition, serum level of decoy receptor 3 (DcR3) will be tested. The study will collect the blood samples from 350 healthy persons and 350 persons infected with dengue fever.

Enrollment: 700 estimated patients

Sex: All

Volunteers: Accepts Healthy Volunteers

Inclusion criteria

• Clinical diagnosis of Dengue fever

Exclusion criteria

• none

Trial design

700 participants in 3 patient groups

healthy

Treatment:

Other: case/control

DF

Treatment:

Other: case/control

DHF

Treatment:

Other: case/control