Investigation of the Prevalence of Hepatopulmonary Syndrome in Cirrhosis Patients Caused by Hepatitis B in Western China

A

Army Medical University

Status

Unknown

Conditions

Hepatopulmonary Syndrome

Study type

Observational

Funder types

Other

Identifiers

NCT03435406
CEE-HBV

Details and patient eligibility

About

to investigate the prevalence of hepatopulmonary syndrome in cirrhosis patients caused by Hepatitis B in western China

Full description

Hepatopulmonary syndrome (HPS) occurs in approximately 4%-29% of cirrhotic patients and influences mortality. China has 100 million Hepatitis B virus (HBV) carriers and Chronic HBV infection is well-recognized risk factor for cirrhosis.But little is known about the prevalence of HPS in cirrhosis patients caused by HBV in western China. The aim of this study was to investigate the HPS incidence, and the signs, symptoms, arterial blood gas, and BMP9 in the serum of the patients.

Enrollment

300 estimated patients

Sex

All

Ages

18 to 80 years old

Volunteers

No Healthy Volunteers

Inclusion criteria

  • Age: 18-80 years old;
  • American association of anesthesiologists(ASA) score: I-III;
  • Ability to comply with research programmes;
  • Voluntary participation in the study;
  • Has the history of HBV infection;
  • No primary cardiopulmonary disease (heart disease, emphysema, pneumonia, asthma, etc.)

Exclusion criteria

  • Severe heart, lung, kidney disease coexisted;
  • American association of anesthesiologists(ASA) score≥IV; forced expiratory volume at one second (FEV1) or forced vital capacity (FVC) <70%, or FEV1 / FVC <0.70;
  • Mental state could not cooperate
  • Absence of written informed consent.

Trial design

300 participants in 2 patient groups

cirrhosis with HPS
Description:
Diagnosed as HPS
cirrhosis without HPS
Description:
Not Diagnosed as HPS

Trial contacts and locations

1

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Central trial contact

tang xi, md; Yi Bin, PhD

Data sourced from clinicaltrials.gov

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