Investigation of the Relationship Between Salivary Histatine-5 Level and Vaginal Candidiasis in Women

Usak State Hospital

Status: Completed

Conditions: Candidiasis; Vaginal Infection

Treatments: Other: salivary sample

Study type: Observational

Funder types: Other

Identifiers

NCT05044156

Usak State Hospital

Details and patient eligibility

About

The low Histatine-5 (HST-5) level of the saliva can lead to vaginal candidiasis. Because HST-5 level in the saliva can effect vaginal Ph, flora and local defence mechanisms.

Histatine-5 is secreted in the parotis and submandibular glands. İt riches histidine amino ascid and have antifungal activity. Salivary proteins and their plasma levels were found as similar in the literature.

Full description

Women with regularly menstrual cycle will enroll in the study than will separate two groups:

Study group: women with vaginal candidiasis ( diagnosed by clinic and lab.)

Control group: women ( not have any vaginal infections candida and others)

Saliva samples will be taken from two groups than HST-5 level will be analyzed. Finally HST-5 levels of the two groups will be compared .

Women with diabetes, immun deficiency, pregnancy, virgin, menopausal period , premature ovarian failure will be excluded.

Enrollment: 90 patients

Sex: Female

Ages: 18 to 50 years old

Volunteers: Accepts Healthy Volunteers

Inclusion and exclusion criteria

Inclusion Criteria: women with regularly menstrual cycle , diagnosed candidal vaginosis and not have any vaginal infection.

Exclusion Criteria: diabetes, immun deficiency, menopause, premature ovarian failure, pregnancy, virgin

Trial design

90 participants in 2 patient groups

Case group

Description:

vaginal candidiasis

Treatment:

Other: salivary sample

Control group

Description:

healty women

Treatment:

Other: salivary sample