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Investigation of the Relationship Between Sarcopenia and Balance, Fear of Falling and Fall Risk in Older Female Patients

K

Konya Beyhekim Training and Research Hospital

Status

Completed

Conditions

Sarcopenia

Treatments

Diagnostic Test: Evaluation of balance status, fear of falling and risk of falling in patients with sarcopenia.
Diagnostic Test: Evaluation of balance status, fear of falling and risk of falling in patients with severe sarcopenia.
Diagnostic Test: Evaluation of balance status, fear of falling and risk of falling in patients with probable sarcopenia.
Diagnostic Test: valuation of balance status, fear of falling and risk of falling in patients non-sarcopenia.

Study type

Observational

Funder types

Other

Identifiers

NCT06277193
KonyaBeyhekimTRH

Details and patient eligibility

About

This study (study type: cross-sectional) aims to investigate the relationship of sarcopenia level with balance, fear of falling and risk of falling in the elderly female population. In the first stage, 166 participants were divided into two groups: sarcopenia and non-sarcopenia. Afterwards, they were categorized according to sarcopenia level (probable sarcopenia group, sarcopenia group, severe sarcopenia group, group without sarcopenia) and comparisons were made between these subgroups. Then, they were evaluated with various scales and tests (in terms of balance, fear of falling and risk of falling).

Full description

The world population is experiencing an aging trend accompanied by declines in fertility and mortality rates. This aging process varies among countries and regions. The aging of societies leads to an increase in health and socioeconomic problems. Sarcopenia is just one of the problems that arise with aging.

Sarcopenia is defined as a progressive syndrome associated with a general loss of muscle mass and strength, leading to a decrease in physical function, deterioration in quality of life, and even adverse outcomes such as death. Although sarcopenia is primarily defined as a syndrome associated with the elderly population, it can also be observed in non-elderly individuals with other diseases or conditions. Therefore, due to its higher prevalence in the elderly population, it can also be referred to as a geriatric syndrome.

The prevalence of sarcopenia varies depending on the measurement methods used to assess muscle mass, muscle strength, and muscle performance, as well as the population studied. The frequency of sarcopenia can range from 8% to 40% in populations aged 60 and over. Muscle mass decreases linearly in both men and women after the age of 40. These losses in muscle mass continue at a rate of 8% per decade up to the age of 70 and increase to 15% in the subsequent decades. Total loss can reach up to 50% in the eighth decade.

The etiology of sarcopenia is multifactorial. Aging, certain chronic diseases, immobility, sedentary lifestyle, and nutritional deficiencies can contribute to sarcopenia. While sarcopenia can sometimes be attributed to a single cause, in most cases, a single cause cannot be identified. Sarcopenia can generally be classified into two main categories: primary and secondary. Primary sarcopenia is solely associated with the aging process, while secondary sarcopenia develops due to one or more causes (such as immobility, comorbidities, nutrition). However, it may not always be possible to make a clear distinction between primary and secondary sarcopenia.

Various imaging methods such as computerized tomography (CT), magnetic resonance imaging (MRI), or dual-energy X-ray absorptiometry (DEXA) can be used to determine muscle mass in the diagnosis of sarcopenia, while anthropometric measurements such as bioimpedance analysis or upper mid-arm circumference and calf circumference may also be applied. Muscle strength is generally measured using a hand dynamometer, while methods such as walking tests, sit-to-stand tests, or stair climbing tests can be used to assess muscle performance.

Individuals who have results below critical values in muscle strength measurement but have normal muscle mass, muscle quality, and physical performance values are defined as probable sarcopenia. If there is also low muscle mass in addition to decreased muscle strength, this condition is classified as sarcopenia. If there is a decrease in muscle mass or quality along with decreased muscle strength and physical performance, this condition can be classified as severe sarcopenia.

Balance is an expression of postural adaptation to changes in the center of gravity during rest or movement. Factors that maintain balance are the integration of vestibular, proprioceptive, and visual data within the central nervous system and coordinated muscle activity resulting from voluntary or involuntary reflex activity. Disruption of balance predisposes to falls. A fall is a condition that usually results in an unwanted change in position, without a significant intrinsic event, strong external force, or intentional movement, usually on the ground or at a lower level. It can also be defined as an uncorrectable change in position.

One of the psychological consequences of falling is fear of falling. This is defined as an anxiety condition that leads to avoidance of physical activity after a fall. This condition is often accompanied by anxiety and loss of confidence. Fear of falling may decrease over time or become continuous. Previous fall events, advanced age, being female, vision problems, depressive mood, polypharmacy, and balance disorders can be among the risk factors for fear of falling.

Studies have found that sarcopenia is associated with many diseases, reduces quality of life, increases dependency, affects mortality, and increases hospitalizations. However, studies investigating the relationship between balance, risk of falling, fear of falling, and sarcopenia are limited in the literature. This study aims to investigate the relationship between the level of sarcopenia and balance, fear of falling, and risk of falling in an elderly female population.

Enrollment

166 patients

Sex

Female

Ages

65+ years old

Volunteers

Accepts Healthy Volunteers

Inclusion criteria

  1. Being over 60 years old
  2. Being a woman

Exclusion criteria

  1. Those under 60 years of age
  2. Male ones
  3. Hand deformities
  4. Advanced knee osteoarthritis
  5. Advanced hand osteoarthritis
  6. Advanced osteoarthritis in the waist and hip area
  7. History of Carpal Tunnel Syndrome
  8. Communication disorders
  9. Muscle diseases
  10. Root compressions
  11. History of upper and lower extremity spine surgery, prostheses and previous fracture history
  12. Those with advanced kyphosis and scoliosis
  13. Those with serious neck problems
  14. Lumbar spinal stenosis
  15. Those with decompensated heart, liver and kidney failure
  16. Those who have any disease (neurological, orthopedic, metabolic, etc.) that causes balance disorders
  17. Those who use medication that may cause balance disorders
  18. Those with severe hearing and vision impairment
  19. History of antidepressant, anticholinergic, benzodiazepine and anxiolytic use in the last 3 months
  20. Those with major psychiatric illness
  21. Those who use alcohol regularly
  22. Patients with pacemakers
  23. Those with immobility, those whose mobilization is limited for some reason

Trial design

166 participants in 4 patient groups

Non-sarcopenia group
Description:
The diagnosis of sarcopenia was determined using EWGSOP2(The European Working Group on Sarcopenia in Older People) criteria. To evaluate walking speed, muscle strength and muscle mass, hand grip test, bioimpedance and 4-meter walking test were performed on each patient, respectively. Those who had results above the critical values determined in muscle strength measurement according to criteria were defined as the group without sarcopenia.
Treatment:
Diagnostic Test: valuation of balance status, fear of falling and risk of falling in patients non-sarcopenia.
Probable sarcopenia group
Description:
Individuals with results below the critical values determined in muscle strength measurement were defined as the probable sarcopenia group if their muscle mass and physical performance values were normal.
Treatment:
Diagnostic Test: Evaluation of balance status, fear of falling and risk of falling in patients with probable sarcopenia.
Sarcopenia group
Description:
If low muscle mass is present in addition to the decrease in muscle strength, this condition is classified as sarcopenia.
Treatment:
Diagnostic Test: Evaluation of balance status, fear of falling and risk of falling in patients with sarcopenia.
Severe sarcopenia group
Description:
If there is a decrease in muscle mass and physical performance along with muscle strength, this condition can be classified as severe sarcopenia.
Treatment:
Diagnostic Test: Evaluation of balance status, fear of falling and risk of falling in patients with severe sarcopenia.

Trial contacts and locations

1

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Data sourced from clinicaltrials.gov

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