Investigation of the Role of Human Papilloma Virus (HPV) in the Prognosis of Head and Neck Cancer (ARCAGE-NWE)

University of Aberdeen

Status: Completed

Conditions: Head and Neck Cancer

Study type: Observational

Funder types: Other

Identifiers

NCT02049177

2/084/13

Details and patient eligibility

About

Human papilloma virus (HPV) is a recognised cause of some head and neck cancers. Important questions remain however, regarding the role of specific types of HPV, their effect on prognosis and different subtypes of oral, pharyngeal and laryngeal cancer, interaction with other risk factors (such as smoking and alcohol), and potential geographical differences in the effect of HPV.

Via the Alcohol-Related Cancers and Genetic Susceptibility in Europe (ARCAGE) study, which is an international collaboartive case-control study conducted in 15 centres in 11 European countries, and pooling our results with the HPV-AHEAD consortium, we will conduct a systematic analysis of HPV subtypes known or suspected to be involved in head and neck cancer. This will involve investigation of HPV risk by tumour site (oral, oropharynx, hypopharynx, larynx), tumour stage, country, sex and age, and whether risk is modified by exposure to other known or suspected carcinogens including tobacco, alcohol and medical history.

It is intended that this work will contribute to the development of evidence that may feed into treatment protocols for these cancers as well as evaluations of the feasibility for extending HPV vaccine programs.

Enrollment: 141 patients

Sex: All

Ages: 18+ years old

Volunteers: No Healthy Volunteers

Inclusion criteria

• Consent to follow-up and use of tissue samples

Exclusion criteria

• No existing consent

Trial design

141 participants in 1 patient group

Head and Neck Cancer Cases

Description:

Cases of Head and Neck Cancer identified in North West England in 2002/2003. Observational study - no intervention other than usual care.