Investigation on the Current Situation and Risk Factors Analysis of Exocrine Insufficiency in Chronic Pancreatitis (CP-ESRF)

Naval Military Medical University

Status: Completed

Conditions: Chronic Pancreatitis; Pancreatic Exocrine Insufficiency

Treatments: Diagnostic Test: Detection of Pancreatic Exocrine Function in Patients with Chronic Pancreatitis (CP)

Study type: Observational

Funder types: Other

Identifiers

NCT06946108

CP-ESRF

Details and patient eligibility

About

Pancreatic exocrine insufficiency (PEI) is one of the common complications of chronic pancreatitis (CP). Mild to moderate PEI may present with atypical digestive tract symptoms such as abdominal distension and abdominal pain, while severe PEI can lead to related complications such as foul-smelling stools, steatorrhea, weight loss, and malnutrition. Currently, there is no relevant report on the status quo of PEI in Chinese CP patients. This study aims to analyze the status quo of PEI and related risk factors in Chinese CP patients, with the hope of providing safe and effective intervention and treatment methods to improve the quality of life of patients.

Full description

Pancreatic exocrine insufficiency (PEI) is one of the common complications of chronic pancreatitis (CP). Mild to moderate PEI may present with atypical digestive tract symptoms such as abdominal distension and abdominal pain, while severe PEI can lead to related complications such as foul-smelling stools, steatorrhea, weight loss, and malnutrition. Currently, there is no relevant report on the status quo of PEI in Chinese CP patients.This study aims to analyze the current status and related risk factors of PEI in CP patients in China by detecting pancreatic exocrine function with FE-1, in order to provide safe and effective intervention and treatment methods and improve the quality of life of patients.

Enrollment: 1,101 patients

Sex: All

Volunteers: No Healthy Volunteers

Inclusion criteria

1. patients who underwent inpatient care at Shanghai Changhai Hospital (a WHO Collaborating Center for Pancreatology) between June 2022 and September 2024.
2. patients diagnosed with chronic pancreatitis (CP)
3. Voluntarily preserve feces for the detection of fecal elastase-1 (FE-1)

Exclusion criteria

1. Patients who were diagnosed with pancreatic cancer within 2 years after being diagnosed with chronic pancreatitis (CP)
2. patients with groove pancreatitis,
3. patients with autoimmune pancreatitis.

Trial design

1,101 participants in 1 patient group

the patients diagnosed with chronic pancreatitis who underwent inpatient care

Description:

This hospital-based cohort study enrolled patients diagnosed with chronic pancreatitis (CP) who underwent inpatient care at Shanghai Changhai Hospital (a WHO Collaborating Center for Pancreatology) between June 2022 and September 2024,Voluntary retention of fecal samples for FE-1 detection in CP patients

Treatment:

Diagnostic Test: Detection of Pancreatic Exocrine Function in Patients with Chronic Pancreatitis (CP)