Investigation on the Status Quo of Hyperalgesia in Patients After Thoracoscopic Operation and Study on the Effect of Intraoperative Intervention

Fujian Medical University (FJMU)

Status: Enrolling

Conditions: Hyperalgesia; Thoracoscopic Surgery

Treatments: Behavioral: Flurbiprofen axidate combined with noise-cancelling headphones music; Other: Flurbiprofen exate on a drip; Behavioral: Flurbiprofen axidate combined with noise-cancelling headphones

Study type: Interventional

Funder types: Other

Identifiers

NCT06790914

2024KY115

Details and patient eligibility

About

To explore the status quo and influencing factors of hyperpain in patients after thoracoscopic surgery, and to explore the effect of earphone sound isolation during combined operation of flurbiprofen axidate and binaural beat music played by earphone during combined operation on the intervention of hyperpain after thoracoscopic surgery.

Full description

In this study, patients undergoing thoracoscopy radical lung cancer surgery in Union Hospital Affiliated to Fujian Medical University were selected for A randomized controlled trial. Patients were selected according to the inclusion and exclusion criteria, and the patients were randomly divided into group A of flurbiprofen axidate combined with noise-canceling headset music test, group B of flurbiprofen axidate combined with noise-canceling headset test, and the control group for intraoperative intervention study.

Enrollment: 90 estimated patients

Sex: All

Ages: 18+ years old

Volunteers: No Healthy Volunteers

Inclusion criteria

• Patients selected by the same group of surgeons to perform thoracoscopic three-hole radical resection of lung cancer
• Patients ≥18 years old, able to communicate effectively and cooperate with the completion of clinical trials
• ASA grade I-III
• Normal hearing; Patients who have not participated in other trials in the last two months

Exclusion criteria

• Previous history of thoracic surgery
• History of chronic pain and any intake of analgesics 48 hours before surgery; ● Have a history of mental illness, or have taken psychiatric drugs or received psychological treatment in the past six months
• Deformity of the auricle, inability to wear headphones, and failure to cooperate with this study for any reason
• suffering from concurrent severe organ system diseases and hearing impairment
• Incomplete data collection

Trial design

Primary purpose: Supportive Care

Allocation: Randomized

Interventional model: Parallel Assignment

Masking: Double Blind

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90 participants in 3 patient groups, including a placebo group

Flurbiprofen axidate combined with noise-cancelling headphones music

Experimental group

Description:

30min before induction of general anesthesia, flurbiprofen axidate 50mg+ normal saline 50ml at 60 drops /min; After general anesthesia induction, noise-cancelling headphones (Sony WH-1000XM3) were fully covered with both ears, and MP3 (GoGear, Philips) was connected to play music continuously until the headphones were removed after the operation.

Treatment:

Behavioral: Flurbiprofen axidate combined with noise-cancelling headphones music

flurbiprofen axidate combined with noise-cancelling earphone

Experimental group

Description:

30min before induction of general anesthesia, flurbiprofen axidate 50mg+ normal saline 50ml at 60 drops /min; After induction of general anesthesia, noise-cancelling headphones (Sony WH-1000XM3) were applied to cover both ears completely until the headphones were removed at the end of the procedure.

Treatment:

Behavioral: Flurbiprofen axidate combined with noise-cancelling headphones

Flurbiprofen exate on a drip

Placebo Comparator group

Description:

30min before induction of general anesthesia, flurbiprofen axidate 50mg+ normal saline at 60 drops /min.

Treatment:

Other: Flurbiprofen exate on a drip