Investigational TMS Treatment for Depression

White River Junction Veterans Affairs Medical Center

Status: Withdrawn

Conditions: Treatment Resistant Depression; Depression

Treatments: Device: TMS

Study type: Interventional

Funder types: Other U.S. Federal agency

Identifiers

NCT03175887

D17107

Details and patient eligibility

About

This study is aimed to help us learn about the effects of Transcranial Magnetic Stimulation at the forehead versus the left side of the head for treatment of Treatment Resistant Depression.

Full description

While transcranial magnetic stimulation (TMS) to the left dorsolateral prefrontal cortex (DLPFC) is an FDA approved treatment for depression, a growing and converging database suggests the medial prefrontal cortex (MPFC) may be even more critical to the neurobiology of depression and antidepressant treatment response. This study will compare the efficacy of high frequency transcranial madntic stimulation on these two sections of the brain.

Sex: All

Ages: 21 to 70 years old

Volunteers: Accepts Healthy Volunteers

Inclusion criteria

• 21-70 years old
• inadequate response to one current antidepressant medication
• currently depressed

Exclusion criteria

• psychiatric comorbidities

Trial design

Primary purpose: Treatment

Allocation: Randomized

Interventional model: Parallel Assignment

Masking: Single Blind

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0 participants in 2 patient groups

Intervention Arm

Experimental group

Description:

Participants will receive TMS. They will be randomized to either the left dorsolateral prefrontal cortex or the medial prefrontal cortex.

Treatment:

Device: TMS

Treatment Arm

Other group

Description:

After the experimental arm, if a patient was randomized to the medial prefrontal cortex during the experimental arm and it did not work for them, they have the option of returning for a session of TMS to the FDA-approved dorsolateral prefrontal cortex. If they were assigned to the dorsolateral prefrontal cortex, they are not eligible to return for another set of treatment.

Treatment:

Device: TMS