Investigations of Dementia in Parkinson Disease (PIB)

The Washington University

Status

Enrolling

Conditions

Parkinsons

Treatments

Radiation: PiB and VAT

Study type

Observational

Funder types

Other

NIH

Identifiers

NCT02763683

201512032

R01NS075321 (U.S. NIH Grant/Contract)

Details and patient eligibility

About

The purpose of this study is to use a brain imaging method called Pittsburgh B (PIB) Positron Emission Tomography (PET) and Vesicular Cholinergic Transport (VAT) PET to determine dementia subtypes in patients with Parkinson disease (PD). The ultimate goal of this project is to be able to identify individuals with PD who are at risk of developing dementia, and to distinguish the underlying cause of dementia.

Full description

The purpose of this study is to use a brain imaging method called PIB PET and VAT PET to determine dementia subtypes in patients with Parkinson disease (PD). The ultimate goal of this project is to be able to identify individuals with PD who are at risk of developing dementia, and to distinguish the underlying cause of dementia. The investigators will be including both PD and normal subjects in this study. This a long term study and we are considering including a total of 320 participants in this protocol.

Enrollment

320 estimated patients

Sex

All

Ages

50+ years old

Volunteers

Accepts Healthy Volunteers

Inclusion criteria

PD patients must exhibit three of the following cardinal signs: rest tremor, rigidity, bradykinesia, or postural instability; or two of these features with one of the first three displaying asymmetry.

Exclusion criteria

history of head trauma, major neurological or psychiatric diseases other than Parkinson disease and dementia, e.g. stroke, multiple sclerosis, depression or schizophrenia.
severe systemic diseases.
inability to lie still for 90 minutes.
metallic implants, pacemakers, or any other contraindication to MRI.
refusal to consent to brain donation.