Involuntary Memories Investigation in Schizophrenia

University Hospital, Strasbourg, France

Status

Terminated

Conditions

Schizophrenia

Treatments

Other: Patients with Schizophrenia

Study type

Interventional

Funder types

Other

Identifiers

NCT03209778

6620

Details and patient eligibility

About

Patients with schizophrenia suffer from autobiographical memory disorders. Patients have difficulty to remember vividly personal past events when they are specifically asked for. Indeed, this task requires a good executive functioning to retrieve precise information stored in long term memory. Interestingly, executive functioning has been showed impaired in schizophrenia and studies showed that their autobiographical memory impairments were directed related to their executive dysfunction.

Yet, in daily life people remember more often autobiographical memories spontaneously, without trying voluntarily to recall them.

In that case, the involuntary recall of personal past events is much less sustained by executive functioning.

In this protocol the investigators would like to investigate and compare subjective characteristics of involuntary and voluntary autobiographical memories in order to highlight the role of executive dysfunction in patients' autobiographical memory impairments.

Enrollment

65 patients

Sex

All

Ages

18 to 55 years old

Volunteers

Accepts Healthy Volunteers

Inclusion criteria

- for patients only
male or female
age limits : 18-55 years old
under the protection of health insurance
who have signed up the consent form
schizophrenia or schizo-affective disorder according to the DSM-5 criteria (APA, 2013).
clinically stable for at least 2 months
patients under guardianship or curatorship need agreement of their legal representative
informed of the results of prior medical examination for controls only
male or female
age limits : 18-55 years old
under the protection of health insurance
who have sign up the consent form
recruited from the general population and matched on gender, age years of schooling
no psychiatric history (DSM-5)

Exclusion criteria

for both patients and controls
current severe or unstable somatic illness
neurological history (brain injury > 15 minutes loss of consciousness , epilepsia, brain surgery...)
current substance use disorder (DSM-5)
current major depressive disorder (CDSS,BDI, HDRS)
mental retardation (IQ < 70, WAIS-4, f-NART)
history of general anesthesia 3 months prior to the experiment
pregnancy declared by the subject
breast feeding
current legal control
in emergency situation
included during exclusion period in another experiment
for controls only
taking of antipsychotic drugs for the 3 weeks prior to inclusion
under guardianship or curatorship