Involvement of Translation Initiation Factors in the Immune Response in the Elderly

Clalit Health Services

Status: Unknown

Conditions: Infection; Elderly Patient

Study type: Observational

Funder types: Other

Identifiers

NCT01215604

MMC10156-2010CTIL

Details and patient eligibility

About

The investigators propose that the translation initiation factors eIF4E and eIF4GI may be involved in resolution of acute inflammation (regardless of age). Furthermore, the investigators suggest that differences in translation initiation factors state of activation may contribute to inflammation. Finally, the investigators hypothesize that differences in translation initiation factors state of activation may underlie the immune compromised state of the very elderly affording additional explanation for the heightened morbidity from infection in this group.

In the current study the investigators aim to test these hypotheses by measuring the levels of eIF4E and eIF4G, their regulators, and targets in elderly (65-84yrs) and very elderly (85yrs<) patients hospitalized at Meir hospital for acute infection and after their recovery (detailed in study design).

Enrollment: 40 estimated patients

Sex: All

Ages: 65+ years old

Volunteers: No Healthy Volunteers

Inclusion criteria

• elderly patients (65<)
• hospitalized for acute infection (fever 38c<, leukocytosis)

Exclusion criteria

• patients with dementia who can not sign informed consent of institutional Helsinki committee
• patient with active cancer with active chemotherapy treatment