Involvement of Viral Infections in the Pathogenesis of Chronic Lymphocytic Thyroiditis (Etude thyrovir)

Centre Hospitalier Universitaire, Amiens

Status

Completed

Conditions

Chronic Lymphocytic Thyroiditis

Autoimmune Diseases

Treatments

Other: Comparison of the prevalences of the parvovirus genome

Study type

Observational

Funder types

Other

Identifiers

NCT03114267

PI11-PR-DESAILLOUD-1

Details and patient eligibility

About

Autoimmune diseases represent a heterogeneous group of pathologies whose etiopathogenic mechanisms are most often unknown. Autoimmune diseases are the leading cause of morbidity and mortality in young women and autoimmune thyroid diseases are the most common.

Viral infections are the main environmental factors suspected of triggering autoimmune diseases. Several viruses are certainly involved, all of which are possibly capable of triggering an autoimmune response. However, the precise identification of the viruses involved remains to be established.

It has been shown for the first time by the 2005 PHRC that enteroviral RNA is present in perioperative specimens of thyroid tissue. However, this case-control study did not show any difference between the thyroid group and the group other thyroid pathologies It has been recently published that Parvovirus is possibly involved in thyroiditis: the parvoviral genome is present in the thyroid tissue of Hashimoto thyroiditis operated and more precisely is present within the thyrocytes itself.

Enrollment

64 patients

Sex

All

Ages

18+ years old

Volunteers

No Healthy Volunteers

Inclusion criteria

Patients participating in PHRC 2005 "involvement of enteroviruses in TLC pathogenesis"
Inclusion of TLC: presence of a significant lymphocyte infiltrate within the thyroid parenchyma defined by the presence of clusters of more than 30 to 50 lymphocytes
Inclusion of controls: absence of significant lymphocyte infiltrate

Exclusion criteria