Iodine Status and Characteristics of Papillary Thyroid Cancer

Shandong First Medical University

Status: Not yet enrolling

Conditions: Papillary Thyroid Carcinoma

Treatments: Dietary Supplement: Iodine suitable; Dietary Supplement: Iodine excess

Study type: Observational

Funder types: Other

Identifiers

NCT06626581

ShandongPH 20240923

Details and patient eligibility

About

The effect of iodine on papillary thyroid cancer has been controversial for many years. The investigators designed a cross-sectional study and aimed to explore the relationship between the serum and urine iodine levels and the clinical and molecular characteristics of papillary thyroid cancer.

Enrollment: 600 estimated patients

Sex: All

Ages: 18 to 65 years old

Volunteers: No Healthy Volunteers

Inclusion criteria

• Age range: 18~65 years old, gender not limited;
• Living in the residential area for at least 5 years;
• Patients diagnosed clinically with thyroid cancer and scheduled for thyroid surgery, with pathological diagnosis of papillary thyroid cancer;
• Complete clinical data: including general information, relevant laboratory tests, pathological reports, surgical reports, ultrasound reports, etc.

Exclusion criteria

• Pathological diagnosis of other types of thyroid cancer;
• Diagnosed with other types of cancer;
• There are serious comorbidities of the heart, liver, and kidneys;

Trial design

600 participants in 2 patient groups

Excessive iodine group

Description:

Residents with papillary thyroid cancer who have lived in excessive iodine areas for a long time (5 years or more). According to the report of Shandong linstitute of Endemic Disease Prevention and Control, three sub centers were selected in excessive iodine group(Jining/Liaocheng/Heze).

Treatment:

Dietary Supplement: Iodine excess

Suitable iodine group

Description:

Residents with papillary thyroid cancer who have lived in suitable iodine areas for a long time (5 years or more). According to the report of Shandong linstitute of Endemic Disease Prevention and Control, three sub centers were selected in suitable iodine group(Jinan/Shenyang/Haerbin).

Treatment:

Dietary Supplement: Iodine suitable