Iodine Supplement Strategies Between Routine Iodine Supplementation and Selective Iodine Supplementation

Chiang Mai University

Status: Completed

Conditions: Iodine Deficiency; Pregnancy Related

Treatments: Dietary Supplement: Triferdine; Dietary Supplement: Triferdine/Ferli-6

Study type: Interventional

Funder types: Other

Identifiers

NCT03078140

4298

Details and patient eligibility

About

Pregnant women who attend at our antenatal clinic will random to 2 groups. First will receive routine iodine supplementation. The other will receive iodinated pill or only iron supplementation base on their urine iodine status.

Enrollment: 208 patients

Sex: Female

Volunteers: No Healthy Volunteers

Inclusion criteria

• first visit for antenatal care in the first trimester
• singleton pregnancy
• delivered at Maharaj Nakorn Chiangmai Hospital

Exclusion criteria

• thyroid disease which diagnosed before pregnancy or currently
• history of thyroid gland surgery or iodine ablation therapy
• received iodine supplement before pregnancy
• received any medication for thyroid disease treatment, within 6 weeks postpartum women or breast feeding period
• family history of thyroid disease
• having underlying disease or contraindication which cannot received iodine supplement
• loss follow-up or incomplete data.

Trial design

Primary purpose: Prevention

Allocation: Randomized

Interventional model: Parallel Assignment

Masking: None (Open label)

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208 participants in 2 patient groups

Triferdine

Active Comparator group

Description:

Triferdine 1 tablet by mouth daily. Start after 1st trimester until delivery

Treatment:

Dietary Supplement: Triferdine

Triferdine/Ferli-6

Active Comparator group

Description:

Triferdine or ferli-6 1 tablet by mouth daily base on iodine status. The supplement will give after 1st trimester until delivery

Treatment:

Dietary Supplement: Triferdine/Ferli-6